LGALS3

LGALS3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI, 4BLJ, 4BM8, 4JC1, 4JCK, 4LBJ, 4LBK, 4LBL, 4LBM, 4LBN, 4LBO, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 4XBN, 5H9R, 5H9P
Dynodwyr
Cyfenwau	LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3
Dynodwyr allanol	OMIM: 153619 HomoloGene: 37608 GeneCards: LGALS3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • chemoattractant activity • IgE binding • laminin binding • carbohydrate binding • RNA binding • oligosaccharide binding • protein phosphatase inhibitor activity • protein phosphatase binding Cydrannau o'r gell • cytoplasm • bilen • GO:0005578 extracellular matrix • cellbilen • immunological synapse • mitochondrial inner membrane • spliceosomal complex • extracellular exosome • cnewyllyn cell • extracellular space • secretory granule membrane • ficolin-1-rich granule membrane • galectin complex • extracellular region • cell surface • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of endocytosis • cell differentiation • regulation of T cell proliferation • negative regulation of immunological synapse formation • epithelial cell differentiation • monocyte chemotaxis • proses y system imiwnedd • mRNA processing • eosinophil chemotaxis • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of mononuclear cell migration • neutrophil chemotaxis • negative regulation of T cell receptor signaling pathway • mononuclear cell migration • positive regulation of calcium ion import • macrophage chemotaxis • regulation of T cell apoptotic process • RNA splicing • positive regulation of dendritic cell differentiation • regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • positive chemotaxis • innate immune response • neutrophil degranulation • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of myeloid cell differentiation • positive regulation of protein homodimerization activity • positive regulation of protein localization to plasma membrane • negative regulation of protein tyrosine phosphatase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3958	n/a
Ensembl	ENSG00000131981	n/a
UniProt	P17931	n/a
RefSeq (mRNA)	NM_001177388 NM_002306 NM_001357678	n/a
RefSeq (protein)	NP_002297 NP_001344607	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LGALS3 yw LGALS3 a elwir hefyd yn Galectin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LGALS3.

• "Expression and Distribution of Galectin-3 in Chromophobe and Papillary Carcinomas. ". Anticancer Res. 2018. PMID 29277781.
• "Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. ". Biochem Biophys Res Commun. 2018. PMID 29137980.
• "Influence of LGALS3 gene polymorphisms on susceptibility and prognosis of dilated cardiomyopathy in a Northern Han Chinese population. ". Gene. 2018. PMID 29129812.
• "Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity. ". Scand J Immunol. 2017. PMID 28990250.
• "Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function.". Biochem J. 2017. PMID 28986508.