LDB1

LDB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2XJY, 2XJZ, 2YPA
Dynodwyr
Cyfenwau	LDB1, CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
Dynodwyr allanol	OMIM: 603451 HomoloGene: 2891 GeneCards: LDB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein homodimerization activity; • GO:0001106 transcription corepressor activity; • LIM domain binding; • chromatin binding; • protein self-association; • GO:0001948, GO:0016582 protein binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • enzyme binding; • GO:0001104 transcription coregulator activity;
Cydrannau o'r gell	• transcription regulator complex; • cnewyllyn cell; • cell leading edge; • nucleoplasm; • beta-catenin-TCF complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• hair follicle development; • transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; • epithelial structure maintenance; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of hemoglobin biosynthetic process; • somatic stem cell population maintenance; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • gastrulation with mouth forming second; • cerebellar Purkinje cell differentiation; • regulation of DNA-templated transcription, elongation; • head development; • histone H3-K4 acetylation; • Wnt; • transcription by RNA polymerase II; • transcription, DNA-templated; • cerebellum development; • negative regulation of erythrocyte differentiation; • multicellular organism development; • neuron differentiation; • anterior/posterior axis specification; • cellular component assembly; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cell adhesion; • regulation of focal adhesion assembly; • regulation of cell migration; • regulation of kinase activity; • regulation of hematopoietic stem cell differentiation; • GO:1901227 negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	8861
	n/a
	ENSG00000198728
	n/a
	Q86U70
	n/a
	NM_001113407; NM_003893; NM_001321612
	n/a
	NP_001106878; NP_001308541; NP_003884
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LDB1 yw LDB1 a elwir hefyd yn LIM domain binding 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LDB1.

NLI
CLIM2
LDB-1
CLIM-2

Llyfryddiaeth

"1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex. ". J Biomol NMR. 2002. PMID 12153047.
"Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2. ". J Hum Genet. 1999. PMID 10083735.
"Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1. ". Cytogenet Cell Genet. 1999. PMID 10640831.
"LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. ". Mol Cell Biol. 2015. PMID 26598604.
"Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134.". Biochem J. 2010. PMID 20423330.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LDB1 - Cronfa NCBI

[1]

[2]

LDB1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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