KITLG

KITLG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EXZ, 1SCF, 2E9W
Dynodwyr
Cyfenwau	KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
Dynodwyr allanol	OMIM: 184745 HomoloGene: 692 GeneCards: KITLG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • stem cell factor receptor binding • GO:0001948, GO:0016582 protein binding • growth factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • cytokine activity Cydrannau o'r gell • integral component of membrane • bilen • extracellular region • Cytosgerbwd • cell projection • filopodium • lamellipodium • cytoplasm • cellbilen • extracellular space Prosesau biolegol • male gonad development • MAPK cascade • cell adhesion • embryonic hemopoiesis • cell population proliferation • GO:0072468 signal transduction • phosphatidylinositol phosphate biosynthetic process • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • positive regulation of cell population proliferation • ovarian follicle development • neural crest cell migration • positive regulation of leukocyte migration • positive regulation of myeloid leukocyte differentiation • negative regulation of mast cell apoptotic process • ectopic germ cell programmed cell death • negative regulation of apoptotic process • positive regulation of MAP kinase activity • positive regulation of melanocyte differentiation • positive regulation of Ras protein signal transduction • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of mast cell proliferation • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of hematopoietic stem cell proliferation • positive regulation of hematopoietic progenitor cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4254	n/a
Ensembl	ENSG00000049130	n/a
UniProt	P21583	n/a
RefSeq (mRNA)	NM_003994 NM_000899	n/a
RefSeq (protein)	NP_000890 NP_003985	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KITLG yw KITLG a elwir hefyd yn KIT ligand (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q21.32.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KITLG.

• "Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes. ". Biochem Biophys Res Commun. 2017. PMID 28456630.
• "Insights into the transmembrane helix associations of kit ligand by molecular dynamics simulation and TOXCAT. ". Proteins. 2017. PMID 28370370.
• "Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases. ". Genet Mol Res. 2017. PMID 28290616.
• "Effects of Stem Cell Factor on Cell Homing During Functional Pulp Regeneration in Human Immature Teeth. ". Tissue Eng Part A. 2017. PMID 27762658.
• "Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor.". Am J Reprod Immunol. 2016. PMID 26791471.