KDM4C

KDM4C
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2XDP, 2XML, 4XDO, 4XDP, 5FJK, 5FJH
Dynodwyr
Cyfenwau	KDM4C, GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, lysine demethylase 4C
Dynodwyr allanol	OMIM: 605469 HomoloGene: 41004 GeneCards: KDM4C
EC number	1.14.11.66
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • histone H3-methyl-lysine-9 demethylase activity • dioxygenase activity • metal ion binding • chromatin binding • enzyme binding • histone demethylase activity • androgen receptor binding • zinc ion binding • histone H3-methyl-lysine-36 demethylase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • methylated histone binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • pericentric heterochromatin • histone methyltransferase complex Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of cell population proliferation • blastocyst formation • regulation of gene expression • GO:1901313 positive regulation of gene expression • histone H3-K9 demethylation • positive regulation of neuron differentiation • negative regulation of histone H3-K9 trimethylation • regulation of stem cell population maintenance • regulation of stem cell differentiation • histone H3-K36 demethylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:1901227 negative regulation of transcription by RNA polymerase II • chromatin remodeling • stem cell population maintenance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23081	n/a
Ensembl	ENSG00000107077	n/a
UniProt	Q9H3R0	n/a
RefSeq (mRNA)	NM_001146694 NM_001146695 NM_001146696 NM_001304339 NM_001304340 NM_001304341 NM_015061 NM_001353997 NM_001353998 NM_001353999 NM_001354000 NM_001354001	n/a
RefSeq (protein)	NP_001140167 NP_001140168 NP_001291268 NP_001291269 NP_001291270 NP_055876 NP_001340926 NP_001340927 NP_001340928 NP_001340929 NP_001340930	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM4C yw KDM4C a elwir hefyd yn Lysine demethylase 4C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9p24.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM4C.

• "Synthesis and Characterisation of Substrate-Based Peptides as Inhibitors of Histone Demethylase KDM4C. ". Protein Pept Lett. 2016. PMID 27295953.
• "Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C). ". J Biol Chem. 2016. PMID 26747609.
• "Jumonji domain containing 2C promotes cell migration and invasion through modulating CUL4A expression in lung cancer. ". Biomed Pharmacother. 2017. PMID 28236704.
• "KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer. ". Breast Cancer (Auckl). 2016. PMID 27840577.
• "KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression.". Neoplasia. 2016. PMID 27742014.