KDM4A

KDM4A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2GF7, 2GFA, 2GP3, 2GP5, 2OQ6, 2OQ7, 2OS2, 2OT7, 2OX0, 2P5B, 2PXJ, 2Q8C, 2Q8D, 2Q8E, 2QQR, 2QQS, 2VD7, 2WWJ, 2YBK, 2YBP, 2YBS, 3NJY, 3PDQ, 3RVH, 3U4S, 4AI9, 4BIS, 4GD4, 4URA, 4V2V, 4V2W, 5D6X, 5F5I, 5A7S, 5F2S, 5A7N, 5A7Q, 5A7O, 5F2W, 5D6W, 5F32, 5FPV, 5A7P, 5A7W, 5F3I, 5A80, 5F37, 5F3E, 5F39, 5F3G, 5F3C, 5D6Y, 5FYC, 5FYI, 5FY8, 5FWE, 5ANQ, 5FYH
Dynodwyr
Cyfenwau	KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A, lysine demethylase 4A
Dynodwyr allanol	OMIM: 609764 HomoloGene: 27780 GeneCards: KDM4A
EC number	1.14.11.69 1.14.11.66, 1.14.11.69
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• dioxygenase activity; • metal ion binding; • methylated histone binding; • GO:0001948, GO:0016582 protein binding; • histone H3-methyl-lysine-36 demethylase activity; • oxidoreductase activity; • ubiquitin protein ligase binding; • histone H3-methyl-lysine-9 demethylase activity; • zinc ion binding; • histone demethylase activity; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • chromatin binding;
Cydrannau o'r gell	• nucleoplasm; • fibrillar center; • cytosol; • cnewyllyn cell; • pericentric heterochromatin; • cytoplasm; • histone methyltransferase complex;
Prosesau biolegol	• histone demethylation; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of gene expression; • transcription, DNA-templated; • GO:0022415 viral process; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of autophagy; • histone H3-K9 demethylation; • histone H3-K36 demethylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:1901313 positive regulation of gene expression; • cardiac muscle hypertrophy in response to stress; • response to nutrient levels; • positive regulation of neuron differentiation; • negative regulation of astrocyte differentiation; • negative regulation of cell death; • negative regulation of histone H3-K9 trimethylation; • chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologau
	9682
	n/a
	ENSG00000066135
	n/a
	O75164
	n/a
	NM_014663
	n/a
	NP_055478
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM4A yw KDM4A a elwir hefyd yn Lysine demethylase 4A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p34.2-p34.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM4A.

JMJD2
JHDM3A
JMJD2A
TDRD14A

Llyfryddiaeth

"Identification and characterization of PKF118-310 as a KDM4A inhibitor. ". Epigenetics. 2017. PMID 27767379.
"Downregulation of KDM4A Suppresses the Survival of Glioma Cells by Promoting Autophagy. ". J Mol Neurosci. 2016. PMID 27514525.
"KDM4 Inhibition Targets Breast Cancer Stem-like Cells. ". Cancer Res. 2017. PMID 28883001.
"SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. ". PLoS Pathog. 2017. PMID 28212444.
"The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations.". ACS Chem Biol. 2017. PMID 28051298.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KDM4A - Cronfa NCBI

[1]

[2]

KDM4A

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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