KAT8

KAT8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2GIV, 2PQ8, 2Y0M, 3QAH, 3TOA, 3TOB, 4DNC
Dynodwyr
Cyfenwau	KAT8, MOF, MYST1, ZC2HC8, hMOF, lysine acetyltransferase 8, LIGOWS
Dynodwyr allanol	OMIM: 609912 HomoloGene: 41676 GeneCards: KAT8
EC number	2.3.1.48
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • transcription factor binding; • metal ion binding; • histone acetyltransferase activity (H4-K8 specific); • histone acetyltransferase activity; • histone acetyltransferase activity (H4-K5 specific); • methylated histone binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase activity (H4-K16 specific); • enzyme binding; • acetyltransferase activity; • acyltransferase activity; • GO:0031493 histone binding;
Cydrannau o'r gell	• nucleoplasm; • Cromosom; • MLL1 complex; • histone acetyltransferase complex; • cnewyllyn cell; • kinetochore; • MSL complex; • nuclear matrix;
Prosesau biolegol	• myeloid cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • histone H4-K5 acetylation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • regulation of autophagy; • histone H4-K16 acetylation; • GO:0045996 negative regulation of transcription, DNA-templated; • histone H4-K8 acetylation; • histone acetylation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	84148
	n/a
	ENSG00000103510
	n/a
	Q9H7Z6
	n/a
	NM_032188; NM_182958
	n/a
	NP_115564; NP_892003
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KAT8 yw KAT8 a elwir hefyd yn Lysine acetyltransferase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KAT8.

MOF
hMOF
MYST1
ZC2HC8

Llyfryddiaeth

"The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells. ". Cell Reprogram. 2015. PMID 26091365.
"Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma. ". Int J Oncol. 2015. PMID 25873202.
"Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. ". J Biol Chem. 2016. PMID 27382063.
"KAT8 Regulates Androgen Signaling in Prostate Cancer Cells. ". Mol Endocrinol. 2016. PMID 27268279.
"A multifaceted role for MOF histone modifying factor in genome maintenance.". Mech Ageing Dev. 2017. PMID 27038808.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] KAT8 - Cronfa NCBI

[1]

[2]

KAT8

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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