ITPKB

ITPKB
Dynodwyr
Cyfenwau	ITPKB, IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37, inositol-trisphosphate 3-kinase B
Dynodwyr allanol	OMIM: 147522 HomoloGene: 1672 GeneCards: ITPKB
EC number	2.7.1.127
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • calmodulin binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • inositol-1,4,5-trisphosphate 3-kinase activity Cydrannau o'r gell • cytosol • bilen • cnewyllyn cell Prosesau biolegol • regulation of protein phosphorylation • cellular response to calcium ion • negative regulation of neutrophil apoptotic process • phosphorylation • common myeloid progenitor cell proliferation • myeloid cell homeostasis • positive regulation of Ras protein signal transduction • inositol phosphate metabolic process • inositol trisphosphate metabolic process • MAPK cascade • cell surface receptor signaling pathway • T cell differentiation • positive thymic T cell selection • negative regulation of myeloid cell differentiation • positive regulation of alpha-beta T cell differentiation • thymic T cell selection • GO:0072468 signal transduction • inositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3707	n/a
Ensembl	ENSG00000143772	n/a
UniProt	P27987	n/a
RefSeq (mRNA)	NM_002221 NM_001388404	n/a
RefSeq (protein)	NP_002212	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITPKB yw ITPKB a elwir hefyd yn Inositol-trisphosphate 3-kinase B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q42.12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITPKB.

• "Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. ". Brain. 2014. PMID 24401760.
• "A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells. ". Cell Signal. 2012. PMID 22446005.
• "Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope. ". J Biol Chem. 2011. PMID 21148483.
• "Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences. ". Biol Cell. 2006. PMID 16354157.
• "Cloning and expression of a full-length cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase B.". Biochem Biophys Res Commun. 2002. PMID 11846419.