ITGAV

ITGAV
Strwythurau PDB Human UniProt search: H0WK80%20or%20H7BZG1 PDBe H0WK80,H7BZG1 RCSB Rhestr o ddynodwyr PDB 1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Dynodwyr
Cyfenwau	ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
Dynodwyr allanol	OMIM: 193210 HomoloGene: 20510 GeneCards: ITGAV
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transforming growth factor beta binding • metal ion binding • voltage-gated calcium channel activity • virus receptor activity • protein kinase C binding • protease binding • extracellular matrix protein binding • extracellular matrix binding • fibronectin binding • opsonin binding • insulin-like growth factor I binding • GO:0001948, GO:0016582 protein binding • fibroblast growth factor binding • neuregulin binding • coreceptor activity • C-X3-C chemokine binding • signaling receptor binding • peptide binding • integrin binding Cydrannau o'r gell • lamellipodium membrane • integrin alphav-beta3 complex • extracellular exosome • alphav-beta3 integrin-IGF-1-IGF1R complex • integral component of membrane • integrin alphav-beta5 complex • bilen • integrin alphav-beta8 complex • ruffle membrane • integrin complex • microvillus membrane • filopodium membrane • external side of plasma membrane • phagocytic vesicle • cellbilen • integral component of plasma membrane • cell surface • cytosol • focal adhesion • cell junction • specific granule membrane • integrin alphav-beta6 complex • alphav-beta3 integrin-PKCalpha complex • alphav-beta3 integrin-HMGB1 complex Prosesau biolegol • regulation of phagocytosis • apoptotic cell clearance • endodermal cell differentiation • apolipoprotein A-I-mediated signaling pathway • negative chemotaxis • negative regulation of lipid storage • extracellular matrix organization • heterotypic cell-cell adhesion • positive regulation of cell migration • regulation of apoptotic cell clearance • substrate adhesion-dependent cell spreading • vascular endothelial growth factor receptor signaling pathway • cell-matrix adhesion • GO:0022415 viral process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • blood vessel development • negative regulation of entry of bacterium into host cell • integrin-mediated signaling pathway • calcium ion transmembrane transport • negative regulation of macrophage derived foam cell differentiation • negative regulation of extrinsic apoptotic signaling pathway • leukocyte migration • cell-substrate adhesion • negative regulation of lipoprotein metabolic process • negative regulation of lipid transport • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cell adhesion • ERK1 and ERK2 cascade • cell growth • positive regulation of osteoblast proliferation • cell adhesion • angiogenesis • vasculogenesis • cellular calcium ion homeostasis • positive regulation of cytosolic calcium ion concentration • positive regulation of cell population proliferation • cell migration • neutrophil degranulation • positive regulation of MAPK cascade • cell adhesion mediated by integrin • viral entry into host cell • regulation of transforming growth factor beta activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3685	n/a
Ensembl	ENSG00000138448	n/a
UniProt	P06756	n/a
RefSeq (mRNA)	NM_001144999 NM_001145000 NM_002210	n/a
RefSeq (protein)	NP_001138471 NP_001138472 NP_002201	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGAV yw ITGAV a elwir hefyd yn Integrin alpha-V ac Integrin subunit alpha V (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q32.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGAV.

• "Lack of association between integrin αvβ3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ". Virol Sin. 2017. PMID 28190175.
• "CD51 correlates with the TGF-beta pathway and is a functional marker for colorectal cancer stem cells. ". Oncogene. 2017. PMID 27593923.
• "Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. ". Anticancer Res. 2016. PMID 27466481.
• "Role for the αV Integrin Subunit in Varicella-Zoster Virus-Mediated Fusion and Infection. ". J Virol. 2016. PMID 27279620.
• "Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome.". Oncotarget. 2016. PMID 26918452.