ING2

ING2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WES, 2G6Q
Dynodwyr
Cyfenwau	ING2, ING1L, p33inhibitor of growth family member 2
Dynodwyr allanol	OMIM: 604215 HomoloGene: 20388 GeneCards: ING2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • chromatin binding; • metal ion binding; • methylated histone binding; • GO:0001948, GO:0016582 protein binding; • phosphatidylinositol binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• Golgi apparatus; • cellbilen; • Sin3 complex; • CCAAT-binding factor complex; • cnewyllyn cell; • nucleoplasm; • cytosol;
Prosesau biolegol	• flagellated sperm motility; • positive regulation of transforming growth factor beta receptor signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • negative regulation of apoptotic signaling pathway; • male meiosis I; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • male germ-line stem cell asymmetric division; • seminiferous tubule development; • spermatogenesis; • spermatid development; • regulation of growth; • regulation of response to DNA damage stimulus; • GO:0072468 signal transduction; • negative regulation of cell population proliferation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • positive regulation of histone deacetylation; • regulation of apoptotic process; • regulation of cellular senescence;
	Sources:Amigo / QuickGO
Orthologau
	3622
	n/a
	ENSG00000168556
	n/a
	Q9H160
	n/a
	NM_001291959; NM_001564
	n/a
	NP_001278888; NP_001555
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ING2 yw ING2 a elwir hefyd yn Inhibitor of growth family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q35.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ING2.

ING1L
p33ING2

Llyfryddiaeth

"A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. ". Tumour Biol. 2015. PMID 25613071.
"Nuclear ING2 expression is reduced in osteosarcoma. ". Oncol Rep. 2014. PMID 25190103.
"Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients. ". Neoplasma. 2014. PMID 24712846.
"Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells. ". Dig Dis Sci. 2013. PMID 23864195.
"Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage.". Sci Rep. 2013. PMID 23823870.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ING2 - Cronfa NCBI

[1]

[2]

ING2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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