IL7

IL7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DI2, 3DI3
Dynodwyr
Cyfenwau	IL7, IL-7, interleukin 7
Dynodwyr allanol	OMIM: 146660 HomoloGene: 680 GeneCards: IL7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • interleukin-7 receptor binding • growth factor activity • GO:0005145 cytokine receptor binding • cytokine activity Cydrannau o'r gell • extracellular space • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • GO:0048553 negative regulation of catalytic activity • cell-cell signaling • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of organ growth • negative regulation of apoptotic process • bone resorption • humoral immune response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • animal organ morphogenesis • regulation of gene expression • homeostasis of number of cells within a tissue • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • T cell lineage commitment • positive regulation of B cell proliferation • positive regulation of T cell differentiation • interleukin-7-mediated signaling pathway • regulation of signaling receptor activity • positive regulation of cytokine-mediated signaling pathway • cytokine-mediated signaling pathway • positive regulation of chemokine production • regulation of peptidyl-tyrosine phosphorylation • GO:1901313 positive regulation of gene expression • positive regulation of B cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3574	n/a
Ensembl	ENSG00000104432	n/a
UniProt	P13232	n/a
RefSeq (mRNA)	NM_000880 NM_001199886 NM_001199887 NM_001199888	n/a
RefSeq (protein)	NP_000871 NP_001186815 NP_001186816 NP_001186817	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL7 yw IL7 a elwir hefyd yn Interleukin 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q21.13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL7.

• IL-7

• "Direct effects of interleukin-7 on the function of human T cells in vitro. ". Eur Cytokine Netw. 2016. PMID 28396296.
• "The role of IL-7 in Immunity and Cancer. ". Anticancer Res. 2017. PMID 28314253.
• "Elevated systemic interleukin-7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon. ". Cancer Immunol Immunother. 2017. PMID 27866242.
• "IL-7 suppresses osteogenic differentiation of periodontal ligament stem cells through inactivation of mitogen-activated protein kinase pathway. ". Organogenesis. 2016. PMID 27579861.
• "A combinatorial approach of N-terminus blocking and codon optimization strategies to enhance the soluble expression of recombinant hIL-7 in E. coli fed-batch culture.". Appl Microbiol Biotechnol. 2016. PMID 27342246.