IL1RN

IL1RN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ILR, 1ILT, 1IRA, 1IRP, 2IRT
Dynodwyr
Cyfenwau	IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
Dynodwyr allanol	OMIM: 147679 HomoloGene: 11163 GeneCards: IL1RN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interleukin-1 type I receptor antagonist activity • interleukin-1, type II receptor binding • GO:0001948, GO:0016582 protein binding • interleukin-1, type I receptor binding • interleukin-1 type II receptor antagonist activity • interleukin-1 receptor binding • cytokine activity • interleukin-1 receptor antagonist activity Cydrannau o'r gell • cytoplasm • fesigl • cellbilen • intracellular anatomical structure • extracellular region • extracellular exosome • extracellular space Prosesau biolegol • negative regulation of interleukin-1-mediated signaling pathway • lipid metabolism • response to glucocorticoid • insulin secretion • acute-phase response • negative regulation of heterotypic cell-cell adhesion • negative regulation of cytokine-mediated signaling pathway • inflammatory response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • fever generation • regulation of signaling receptor activity • cytokine-mediated signaling pathway • neutrophil chemotaxis • positive regulation of interleukin-6 production • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of JNK cascade • interleukin-1-mediated signaling pathway • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3557	n/a
Ensembl	ENSG00000136689	n/a
UniProt	P18510	n/a
RefSeq (mRNA)	NM_000577 NM_173841 NM_173842 NM_173843 NM_001318914 NM_001379360	n/a
RefSeq (protein)	NP_000568 NP_001305843 NP_776213 NP_776214 NP_776215 NP_001366289	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL1RN yw IL1RN a elwir hefyd yn Interleukin 1 receptor antagonist (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q14.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL1RN.

• "Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent. ". PLoS One. 2017. PMID 29023524.
• "Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease: Meta-Analysis of Six Population-Based Cohorts. ". Arterioscler Thromb Vasc Biol. 2017. PMID 28428221.
• "Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis. ". PLoS One. 2017. PMID 28384207.
• "Interleukin-1 Receptor Antagonist Polymorphism and Birth Timing: Pathway Analysis Among African American Women. ". Nurs Res. 2017. PMID 28252571.
• "The Clinical Significance of Interleukin-1 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis.". PLoS One. 2016. PMID 27105431.