IL10RA

IL10RA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J7V, 1LQS, 1Y6K, 1Y6M, 1Y6N, 5IXI
Dynodwyr
Cyfenwau	IL10RA, CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, Interleukin 10 receptor, alpha subunit, interleukin 10 receptor subunit alpha
Dynodwyr allanol	OMIM: 146933 HomoloGene: 1196 GeneCards: IL10RA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • interleukin-10 binding • signal transducer activity • interleukin-10 receptor activity • signaling receptor activity • GO:0016518 cytokine receptor activity Cydrannau o'r gell • integral component of membrane • bilen • cellbilen • cytoplasm Prosesau biolegol • response to lipopolysaccharide • GO:1904739 regulation of synapse organization • cytokine-mediated signaling pathway • negative regulation of autophagy • positive regulation of receptor signaling pathway via JAK-STAT • ubiquitin-dependent endocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3587	n/a
Ensembl	ENSG00000110324	n/a
UniProt	Q13651	n/a
RefSeq (mRNA)	NM_001558	n/a
RefSeq (protein)	NP_001549	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL10RA yw IL10RA a elwir hefyd yn Interleukin 10 receptor subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q23.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL10RA.

• "Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients. ". APMIS. 2017. PMID 28225209.
• "Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population. ". Clin Rheumatol. 2017. PMID 27796662.
• "Association of the IL-10 receptor A536G (S138G) loss-of-function variant with recurrent miscarriage. ". Am J Reprod Immunol. 2014. PMID 24689510.
• "IL-10R1 (Ser138Gly) functional polymorphism is associated with acute myocardial infarction in Tunisian patients. ". Anadolu Kardiyol Derg. 2014. PMID 24566517.
• "Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.". J Clin Immunol. 2014. PMID 24519095.