IHH

IHH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P
Dynodwyr
Cyfenwau	IHH, BDA1, HHG2, indian hedgehog, Indian hedgehog signaling molecule
Dynodwyr allanol	OMIM: 600726 HomoloGene: 22586 GeneCards: IHH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • metal ion binding • GO:0070122 peptidase activity • hydrolase activity • patched binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • bilen • cellbilen • extracellular region • extracellular space • GO:0005578 extracellular matrix Prosesau biolegol • response to estradiol • maternal process involved in female pregnancy • positive regulation of epithelial cell proliferation • cell-cell signaling • negative regulation of apoptotic process • proteolysis • multicellular organism development • intein-mediated protein splicing • smoothened signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • skeletal system development • ossification • branching involved in blood vessel morphogenesis • osteoblast differentiation • in utero embryonic development • cell fate specification • morphogenesis of a branching structure • vasculature development • heart looping • positive regulation of mesenchymal cell proliferation • epithelial cell morphogenesis • retinal pigment epithelium development • chondrocyte differentiation involved in endochondral bone morphogenesis • proteoglycan metabolic process • pattern specification process • positive regulation of cell population proliferation • embryonic pattern specification • cell differentiation • vitelline membrane formation • pancreas development • positive regulation of collagen biosynthetic process • negative regulation of T cell differentiation in thymus • negative regulation of immature T cell proliferation in thymus • positive regulation of T cell differentiation in thymus • multicellular organism growth • chondrocyte proliferation • regulation of growth • embryonic digit morphogenesis • camera-type eye development • bone resorption • negative regulation of cell differentiation • positive regulation of smoothened signaling pathway • positive regulation of alpha-beta T cell differentiation • negative regulation of alpha-beta T cell differentiation • negative regulation of eye pigmentation • cell maturation • embryonic digestive tract morphogenesis • embryonic camera-type eye morphogenesis • neuron development • smooth muscle tissue development • cartilage development • camera-type eye photoreceptor cell fate commitment • head morphogenesis • somite development • embryonic skeletal joint development • epithelial cell-cell adhesion • response to mechanical stimulus • liver regeneration • regulation of gene expression Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3549	n/a
Ensembl	ENSG00000163501	n/a
UniProt	Q14623	n/a
RefSeq (mRNA)	NM_002181	n/a
RefSeq (protein)	NP_002172	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IHH yw IHH a elwir hefyd yn Indian hedgehog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IHH.

• BDA1
• HHG2

• "Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. ". Arthritis Res Ther. 2015. PMID 26705100.
• "Indian hedgehog contributes to human cartilage endplate degeneration. ". Eur Spine J. 2015. PMID 25958162.
• "Identification of the fourth duplication of upstream IHH regulatory elements, in a family with craniosynostosis Philadelphia type, helps to define the phenotypic characterization of these regulatory elements. ". Am J Med Genet A. 2015. PMID 25692887.
• "Endogenously produced Indian Hedgehog regulates TGFβ-driven chondrogenesis of human bone marrow stromal/stem cells. ". Stem Cells Dev. 2015. PMID 25519748.
• "Indian hedgehog signaling promotes chondrocyte differentiation in enchondral ossification in human cervical ossification of the posterior longitudinal ligament.". Spine (Phila Pa 1976). 2013. PMID 23883825.