IGFBP5

IGFBP5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BOE, 1H59
Dynodwyr
Cyfenwau	IGFBP5, IBP5, insulin like growth factor binding protein 5
Dynodwyr allanol	OMIM: 146734 HomoloGene: 56489 GeneCards: IGFBP5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • fibronectin binding • insulin-like growth factor binding • growth factor binding • insulin-like growth factor I binding • insulin-like growth factor II binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • insulin-like growth factor ternary complex • extracellular region • insulin-like growth factor binding protein complex • endoplasmic reticulum lumen • extracellular space Prosesau biolegol • negative regulation of smooth muscle cell proliferation • negative regulation of translation • positive regulation of protein kinase B signaling • GO:0007243 intracellular signal transduction • negative regulation of growth • glucose homeostasis • female pregnancy • GO:1904579 cellular response to organic cyclic compound • negative regulation of smooth muscle cell migration • negative regulation of osteoblast differentiation • regulation of glucose metabolic process • negative regulation of cell migration • positive regulation of insulin-like growth factor receptor signaling pathway • regulation of cell growth • osteoblast differentiation • response to growth hormone • glucose metabolic process • negative regulation of insulin-like growth factor receptor signaling pathway • hair follicle morphogenesis • regulation of growth • negative regulation of muscle tissue development • striated muscle cell differentiation • lung alveolus development • negative regulation of skeletal muscle hypertrophy • type B pancreatic cell proliferation • cellular response to cAMP • GO:0072468 signal transduction • mammary gland involution • GO:0010260 heneiddio • post-translational protein modification • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell migration • regulation of insulin-like growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3488	n/a
Ensembl	ENSG00000115461	n/a
UniProt	P24593	n/a
RefSeq (mRNA)	NM_000599	n/a
RefSeq (protein)	NP_000590	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGFBP5 yw IGFBP5 a elwir hefyd yn Insulin like growth factor binding protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGFBP5.

• IBP5

• "Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer. ". Breast Dis. 2016. PMID 27612043.
• "IGFBP5 enhances osteogenic differentiation potential of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells, via the JNK and MEK/Erk signalling pathways. ". Cell Prolif. 2016. PMID 27484838.
• "IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF. ". PLoS One. 2015. PMID 26103640.
• "Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. ". Oncotarget. 2015. PMID 26010068.
• "Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.". Nat Commun. 2014. PMID 25248036.