IGF1

IGF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Dynodwyr
Cyfenwau	IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Dynodwyr allanol	OMIM: 147440 HomoloGene: 515 GeneCards: IGF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • insulin receptor binding • growth factor activity • integrin binding • GO:0001948, GO:0016582 protein binding • insulin-like growth factor receptor binding Cydrannau o'r gell • extracellular region • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • cellbilen • extracellular space Prosesau biolegol • positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • DNA replication • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • cell population proliferation • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • regulation of gene expression • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • Hypertrofedd cyhyrol • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3479	n/a
Ensembl	ENSG00000017427	n/a
UniProt	P05019	n/a
RefSeq (mRNA)	NM_000618 NM_001111283 NM_001111284 NM_001111285	n/a
RefSeq (protein)	NP_000609 NP_001104753 NP_001104754 NP_001104755	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF1 yw IGF1 a elwir hefyd yn Insulin like growth factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q23.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGF1.

• MGF
• IGFI
• IGF-I

• "IGF-1 promotes angiogenesis in endothelial cells/adipose-derived stem cells co-culture system with activation of PI3K/Akt signal pathway. ". Cell Prolif. 2017. PMID 28960620.
• "Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells. ". J Biol Chem. 2017. PMID 28821609.
• "Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. ". Stroke. 2017. PMID 28596451.
• "Serum insulin-like growth factor-I levels are associated with improved white matter recovery after traumatic brain injury. ". Ann Neurol. 2017. PMID 28574152.
• "The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells.". Anticancer Res. 2017. PMID 28551627.