IFIH1

IFIH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RQB, 3B6E, 3GA3, 4GL2
Dynodwyr
Cyfenwau	IFIH1, AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1, interferon induced with helicase C domain 1, IMD95
Dynodwyr allanol	OMIM: 606951 HomoloGene: 32535 GeneCards: IFIH1
EC number	3.6.4.13
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • GO:0008026 helicase activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • RNA binding • double-stranded RNA binding • ribonucleoprotein complex binding • hydrolase activity • ATP binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell Prosesau biolegol • positive regulation of interferon-alpha production • MDA-5 signaling pathway • proses y system imiwnedd • response to virus • protein sumoylation • cytoplasmic pattern recognition receptor signaling pathway in response to virus • negative regulation of type I interferon production • detection of virus • GO:0022415 viral process • innate immune response • regulation of type III interferon production • positive regulation of interferon-beta production • protein deubiquitination • positive regulation of response to cytokine stimulus • cellular response to exogenous dsRNA • defense response to virus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	64135	n/a
Ensembl	ENSG00000115267	n/a
UniProt	Q9BYX4	n/a
RefSeq (mRNA)	NM_022168	n/a
RefSeq (protein)	NP_071451	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IFIH1 yw IFIH1 a elwir hefyd yn Interferon induced with helicase C domain 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q24.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IFIH1.

• "Further evidence for specific IFIH1 mutation as a cause of Singleton-Merten syndrome with phenotypic heterogeneity. ". Am J Med Genet A. 2017. PMID 28319323.
• "Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis. ". Genet Mol Res. 2016. PMID 27813554.
• "Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. ". J Exp Med. 2017. PMID 28606988.
• "Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy. ". Arthritis Rheumatol. 2017. PMID 28605144.
• "A rare coding allele in IFIH1is protective for psoriatic arthritis.". Ann Rheum Dis. 2017. PMID 28501801.