HTRA1

HTRA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JOA, 2YTW, 3NUM, 3NWU, 3NZI, 3TJN, 3TJO, 3TJQ
Dynodwyr
Cyfenwau	HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
Dynodwyr allanol	OMIM: 602194 HomoloGene: 31114 GeneCards: HTRA1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• insulin-like growth factor binding; • growth factor binding; • GO:0070122 peptidase activity; • serine-type peptidase activity; • hydrolase activity; • serine-type endopeptidase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • GO:0005578 extracellular matrix; • cellbilen; • extracellular exosome; • extracellular region; • extracellular space; • collagen-containing extracellular matrix;
Prosesau biolegol	• negative regulation of defense response to virus; • chorionic trophoblast cell differentiation; • positive regulation of epithelial cell proliferation; • placenta development; • dentinogenesis; • negative regulation of transforming growth factor beta receptor signaling pathway; • proteolysis; • negative regulation of BMP signaling pathway; • regulation of cell growth; • extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologau
	5654
	n/a
	ENSG00000166033
	n/a
	Q92743
	n/a
	NM_002775
	n/a
	NP_002766
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTRA1 yw HTRA1 a elwir hefyd yn HtrA serine peptidase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTRA1.

L56
HtrA
ARMD7
ORF480
PRSS11
CARASIL
CADASIL2

Llyfryddiaeth

"Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL. ". Neurology. 2016. PMID 27164673.
"HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration. ". J Stem Cells. 2015. PMID 27125063.
"Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. ". Am J Pathol. 2017. PMID 28941979.
"Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations. ". Lab Invest. 2017. PMID 27841854.
"The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation.". BMC Cancer. 2016. PMID 27809811.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HTRA1 - Cronfa NCBI

[1]

[2]

HTRA1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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