HTR1B

HTR1B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4IAQ, 4IAR
Dynodwyr
Cyfenwau	HTR1B, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12, 5-HT-1B, 5-HT-1D-beta, 5-hydroxytryptamine receptor 1B
Dynodwyr allanol	OMIM: 182131 HomoloGene: 669 GeneCards: HTR1B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • signal transducer activity • G protein-coupled serotonin receptor activity • GO:0001948, GO:0016582 protein binding • neurotransmitter receptor activity • serotonin binding • voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • integral component of plasma membrane • cellbilen • calyx of Held • integral component of presynaptic membrane • serotonergic synapse • dendrite Prosesau biolegol • chemical synaptic transmission • G protein-coupled receptor internalization • regulation of dopamine secretion • regulation of behavior • response to mineralocorticoid • fasogyfyngiad • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular response to alkaloid • negative regulation of serotonin secretion • cellular response to temperature stimulus • negative regulation of synaptic transmission, GABAergic • protein kinase C-activating G protein-coupled receptor signaling pathway • drinking behavior • bone remodeling • feeding behavior • response to ethanol • negative regulation of synaptic transmission, glutamatergic • GO:0072468 signal transduction • adwaith i gocên • positive regulation of vascular associated smooth muscle cell proliferation • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • GO:0035737 animal behavior • presynaptic modulation of chemical synaptic transmission • regulation of synaptic vesicle exocytosis • regulation of presynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3351	n/a
Ensembl	ENSG00000135312	n/a
UniProt	P28222	n/a
RefSeq (mRNA)	NM_000863	n/a
RefSeq (protein)	NP_000854	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTR1B yw HTR1B a elwir hefyd yn 5-hydroxytryptamine receptor 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q14.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTR1B.

• "Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. ". Leukemia. 2017. PMID 28193998.
• "Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine. ". Prog Neuropsychopharmacol Biol Psychiatry. 2017. PMID 28025020.
• "Association between HTR1B alleles and suicidal ideation in individuals with major depressive disorder. ". Neurosci Lett. 2017. PMID 28007644.
• "A family-based association study of the HTR1B gene in eating disorders. ". Rev Bras Psiquiatr. 2016. PMID 27579596.
• "HTR1B gene variants associate with the susceptibility of Raynauds' phenomenon in workers exposed hand-arm vibration.". Clin Hemorheol Microcirc. 2016. PMID 26639766.