HSPA8

HSPA8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ
Dynodwyr
Cyfenwau	HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8
Dynodwyr allanol	OMIM: 600816 HomoloGene: 68524 GeneCards: HSPA8
EC number	3.6.4.10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • heat shock protein binding • unfolded protein binding • phosphatidylserine binding • C3HC4-type RING finger domain binding • GO:0001948, GO:0016582 protein binding • MHC class II protein complex binding • enzyme binding • G protein-coupled receptor binding • ATP binding • ubiquitin protein ligase binding • ATPase activity • RNA binding • cadherin binding • protein-macromolecule adaptor activity • protein folding chaperone activity • chaperone binding • misfolded protein binding • clathrin-uncoating ATPase activity Cydrannau o'r gell • cytoplasm • cytosol • late endosome • blood microparticle • bilen • focal adhesion • ubiquitin ligase complex • melanosome • myelin sheath • cellbilen • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • intracellular anatomical structure • Prp19 complex • nucleoplasm • lysosomal membrane • lysosomal lumen • nucleolus • spliceosomal complex • lumenal side of lysosomal membrane • extracellular exosome • cnewyllyn cell • presynapse • GO:0005578 extracellular matrix • extracellular region • extracellular space • secretory granule lumen • ficolin-1-rich granule lumen • lysosome • autophagosome • axon • dendrite • terminal bouton • presynaptic cytosol • postsynaptic cytosol • chaperone complex • ribonucleoprotein complex Prosesau biolegol • chaperone-mediated autophagy • mRNA splicing, via spliceosome • late endosomal microautophagy • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • regulation of mRNA stability • positive regulation of mRNA splicing, via spliceosome • cellular response to starvation • mRNA processing • chaperone-mediated autophagy translocation complex disassembly • transcription, DNA-templated • chaperone cofactor-dependent protein refolding • regulation of cell cycle • regulation of protein complex stability • ATP metabolic process • response to unfolded protein • clathrin coat disassembly • protein folding • protein refolding • regulation of cellular response to heat • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • GO:0010554 neurotransmitter secretion • GO:0106159 regulation of protein-containing complex assembly • negative regulation of supramolecular fiber organization • regulation of protein import • RNA splicing • protein methylation • neutrophil degranulation • modulation by host of viral process • positive regulation by host of viral genome replication • membrane organization • protein targeting to lysosome involved in chaperone-mediated autophagy • axo-dendritic transport • vesicle-mediated transport • cytokine-mediated signaling pathway • cellular response to heat • Unfolded Protein Response • slow axonal transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3312	n/a
Ensembl	ENSG00000109971	n/a
UniProt	P11142	n/a
RefSeq (mRNA)	NM_006597 NM_153201	n/a
RefSeq (protein)	NP_006588 NP_694881	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSPA8 yw HSPA8 a elwir hefyd yn Heat shock cognate 71 kDa protein a Heat shock protein family A (Hsp70) member 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q24.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSPA8.

• "The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70. ". Stem Cells. 2017. PMID 28026090.
• "A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency. ". Stem Cell Reports. 2015. PMID 26549849.
• "iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma. ". Biomed Res Int. 2015. PMID 26425554.
• "Heat stress induces formation of cytoplasmic granules containing HSC70 protein. ". Dokl Biochem Biophys. 2015. PMID 26335814.
• "A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.". Mol Immunol. 2015. PMID 25953005.