HNF1A

HNF1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IC8, 2GYP
Dynodwyr
Cyfenwau	HNF1A, HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, HNF1 homeobox A, HNF4A, HNF1alpha
Dynodwyr allanol	OMIM: 142410 HomoloGene: 459 GeneCards: HNF1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein dimerization activity • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • renal glucose absorption • insulin secretion • positive regulation of transcription initiation from RNA polymerase II promoter • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • glucose import • regulation of pronephros size • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • natural killer cell differentiation • liver development • pancreas development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6927	n/a
Ensembl	ENSG00000135100	n/a
UniProt	P20823	n/a
RefSeq (mRNA)	NM_000545 NM_001306179	n/a
RefSeq (protein)	NP_000536 NP_001293108 NP_000536.5 NP_001293108.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HNF1A yw HNF1A a elwir hefyd yn Hepatocyte nuclear factor 1-alpha a HNF1 alpha A splice variant 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HNF1A.

• "Relationships between the expression of hepatocyte nuclear factors and factors essential for lipoprotein production in a human mesenchymal stem cell line, UE7T-13. ". Biosci Biotechnol Biochem. 2017. PMID 27838959.
• "TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma. ". Tumour Biol. 2016. PMID 27522523.
• "Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway. ". PLoS One. 2017. PMID 28319127.
• "A molecular case-control study of association of HNF1A gene polymorphisms (rs2259816 and rs7310409) with risk of coronary artery disease in Iranian patients. ". Hum Antibodies. 2017. PMID 28222501.
• "Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population.". Diabetes. 2017. PMID 27899486.