GSTA4

GSTA4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GUL, 1GUM, 3IK7
Dynodwyr
Cyfenwau	GSTA4, GSTA4-4, GTA4, glutathione S-transferase alpha 4
Dynodwyr allanol	OMIM: 605450 HomoloGene: 55585 GeneCards: GSTA4
EC number	2.5.1.18
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glutathione transferase activity • GO:0001948, GO:0016582 protein binding • protein homodimerization activity • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • metabolaeth • glutathione derivative biosynthetic process • glutathione metabolic process • xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2941	n/a
Ensembl	ENSG00000170899	n/a
UniProt	O15217	n/a
RefSeq (mRNA)	NM_001512	n/a
RefSeq (protein)	NP_001503	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSTA4 yw GSTA4 a elwir hefyd yn Glutathione S-transferase alpha 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p12.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GSTA4.

• GTA4
• GSTA4-4

• "Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. ". Biochemistry. 2010. PMID 20085333.
• "Association between polymorphisms in the GSTA4 gene and risk of lung cancer: a case-control study in a Southeastern Chinese population. ". Mol Carcinog. 2009. PMID 18767114.
• "Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappaB translocation. ". Toxicol Appl Pharmacol. 2008. PMID 18485437.
• "Glutathione-S-transferase protects against oxidative injury of endothelial cell tight junctions. ". Endothelium. 2007. PMID 18080870.
• "Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury.". Toxicol In Vitro. 2007. PMID 17553661.