GMNN

GMNN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1T6F, 1UII, 2LP0, 2WVR, 4BRY
Dynodwyr
Cyfenwau	GMNN, Gem, MGORS6, geminin, DNA replication inhibitor, geminin DNA replication inhibitor
Dynodwyr allanol	OMIM: 602842 HomoloGene: 9292 GeneCards: GMNN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • histone deacetylase binding • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity • chromatin binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • animal organ morphogenesis • cell cycle • negative regulation of cell cycle • negative regulation of DNA replication • GO:0045996 negative regulation of transcription, DNA-templated • regulation of DNA replication • positive regulation of chromatin binding • DNA replication preinitiation complex assembly • negative regulation of DNA-dependent DNA replication • GO:0034622 protein-containing complex assembly • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51053	n/a
Ensembl	ENSG00000112312	n/a
UniProt	O75496	n/a
RefSeq (mRNA)	NM_001251989 NM_001251990 NM_001251991 NM_015895	n/a
RefSeq (protein)	NP_001238918 NP_001238919 NP_001238920 NP_056979	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GMNN yw GMNN a elwir hefyd yn Geminin a Geminin, DNA replication inhibitor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GMNN.

• Gem
• MGORS6

• "Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review. ". Biochimie. 2016. PMID 27702582.
• "Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs). ". Int J Hematol. 2016. PMID 27422432.
• "De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome. ". Am J Hum Genet. 2015. PMID 26637980.
• "Geminin inhibits a late step in the formation of human pre-replicative complexes. ". J Biol Chem. 2014. PMID 25231993.
• "Prognostic significance of geminin expression levels in Ki67-high subset of estrogen receptor-positive and HER2-negative breast cancers.". Breast Cancer. 2016. PMID 25082658.