GLI1

GLI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GLI, 4BLB, 4KMD
Dynodwyr
Cyfenwau	GLI1, GLI, GLI family zinc finger 1, PAPA8, PPD1
Dynodwyr allanol	OMIM: 165220 HomoloGene: 3859 GeneCards: GLI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • microtubule binding • chromatin binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • cilium • nucleoplasm • ciliary base • ciliary tip • GO:0035085 axoneme • cnewyllyn cell Prosesau biolegol • epidermal cell differentiation • proximal/distal pattern formation • cell differentiation • pituitary gland development • GO:0009373 regulation of transcription, DNA-templated • positive regulation of smoothened signaling pathway • lung development • positive regulation of cell migration • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • notochord regression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of DNA replication • ventral midline development • multicellular organism development • regulation of smoothened signaling pathway • liver regeneration • response to wounding • regulation of osteoblast differentiation • osteoblast differentiation • spermatogenesis • positive regulation of cell population proliferation • cerebellar cortex morphogenesis • regulation of hepatocyte proliferation • canonical Wnt signaling pathway • smoothened signaling pathway • dorsal/ventral pattern formation • negative regulation of canonical Wnt signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • digestive tract morphogenesis • prostate gland development • positive regulation of cardiac muscle cell proliferation • positive regulation of cell cycle G1/S phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2735	n/a
Ensembl	ENSG00000111087	n/a
UniProt	P08151	n/a
RefSeq (mRNA)	NM_001160045 NM_001167609 NM_005269	n/a
RefSeq (protein)	NP_001153517 NP_001161081 NP_005260	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLI1 yw GLI1 a elwir hefyd yn GLI family zinc finger 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLI1.

• GLI

• "Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma. ". Hum Pathol. 2017. PMID 28965964.
• "Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. ". Cancer Lett. 2017. PMID 28965853.
• "Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography. ". Int J Nanomedicine. 2017. PMID 28458545.
• "Gli1 expression in cancer stem-like cells predicts poor prognosis in patients with lung squamous cell carcinoma. ". Exp Mol Pathol. 2017. PMID 28286162.
• "Gli1 Expression in Human Epiretinal Membranes.". Invest Ophthalmol Vis Sci. 2017. PMID 28134963.