GDNF

GDNF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2V5E, 3FUB, 4UX8
Dynodwyr
Cyfenwau	GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Dynodwyr allanol	OMIM: 600837 HomoloGene: 433 GeneCards: GDNF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • growth factor activity • signaling receptor binding • chemoattractant activity involved in axon guidance Cydrannau o'r gell • extracellular region • intracellular anatomical structure • extracellular space Prosesau biolegol • peristalsis • ureteric bud development • regulation of dopamine uptake involved in synaptic transmission • peripheral nervous system development • sympathetic nervous system development • organ induction • adult locomotory behavior • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • regulation of stem cell differentiation • regulation of morphogenesis of a branching structure • mesenchymal to epithelial transition involved in metanephros morphogenesis • negative regulation of apoptotic process • nervous system development • positive regulation of monooxygenase activity • enteric nervous system development • mRNA stabilization • branching involved in ureteric bud morphogenesis • postganglionic parasympathetic fiber development • positive regulation of dopamine secretion • neural crest cell migration • postsynaptic membrane organization • positive regulation of cell population proliferation • positive regulation of cell differentiation • positive regulation of ureteric bud formation • ureteric bud formation • regulation of gene expression • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • metanephros development • neuron projection development • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • MAPK cascade • axon guidance • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of branching involved in ureteric bud morphogenesis • regulation of signaling receptor activity • dorsal spinal cord development • embryonic organ development • chemoattraction of axon • commissural neuron axon guidance • regulation of semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2668	n/a
Ensembl	ENSG00000168621	n/a
UniProt	P39905	n/a
RefSeq (mRNA)	NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231 NM_199234	n/a
RefSeq (protein)	NP_000505 NP_001177397 NP_001177398 NP_001265027 NP_954701	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GDNF yw GDNF a elwir hefyd yn Glial cell derived neurotrophic factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p13.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GDNF.

• "Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor. ". J Genet. 2016. PMID 27994179.
• "Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia. ". Dig Dis Sci. 2016. PMID 27718082.
• "Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population. ". Biochem Genet. 2016. PMID 27180191.
• "Immunohistochemical Analysis of GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Vitiliginous Skin Lesions. ". J Cutan Med Surg. 2016. PMID 26337382.
• "An Epigenetic Mechanism of High Gdnf Transcription in Glioma Cells Revealed by Specific Sequence Methylation.". Mol Neurobiol. 2016. PMID 26232065.