FTL

FTL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FFX, 2FG4, 2FG8, 3KXU
Dynodwyr
Cyfenwau	FTL, LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
Dynodwyr allanol	OMIM: 134790 HomoloGene: 79330 GeneCards: FTL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • GO:0001948, GO:0016582 protein binding • ferric iron binding • metal ion binding • identical protein binding • ferroxidase activity • ferrous iron binding Cydrannau o'r gell • cytosol • extracellular exosome • intracellular ferritin complex • bilen • extracellular region • azurophil granule lumen • autolysosome • cytoplasm Prosesau biolegol • iron ion homeostasis • iron ion transport • cellular iron ion homeostasis • intracellular sequestering of iron ion • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2512	n/a
Ensembl	ENSG00000087086	n/a
UniProt	P02792	n/a
RefSeq (mRNA)	NM_000146	n/a
RefSeq (protein)	NP_000137	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FTL yw FTL a elwir hefyd yn Ferritin light chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FTL.

• LFTD
• NBIA3

• "Impact of non-transferrin-bound iron (NTBI) in comparison to serum ferritin on outcome after allogeneic stem cell transplantation (ASCT). ". Ann Hematol. 2017. PMID 28585071.
• "Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion. ". Mol Cell Biochem. 2016. PMID 27170377.
• "Ferritin light chain gene mutation in a large Australian family with hereditary hyperferritinemia-cataract syndrome. ". Ophthalmic Genet. 2017. PMID 27096259.
• "Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer's disease. ". Acta Neurobiol Exp (Wars). 2015. PMID 26994418.
• "Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway.". PLoS One. 2016. PMID 26871431.