FRAT1

1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ

FRAT1
FRAT1
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauFRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
Dynodwyr allanolOMIM: 602503 HomoloGene: 3999 GeneCards: FRAT1
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

10023

n/a

Ensembl

ENSG00000165879

n/a

UniProt

Q92837

n/a

RefSeq (mRNA)

NM_181355
NM_005479

n/a

RefSeq (protein)

NP_005470

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FRAT1 yw FRAT1 a elwir hefyd yn FRAT1, WNT signaling pathway regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q24.1.[2]

Llyfryddiaeth

  • "Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. ". PLoS One. 2013. PMID 23613813.
  • "Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. ". Tumour Biol. 2012. PMID 22528942.
  • "Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. ". Oncol Rep. 2016. PMID 27666874.
  • "Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. ". Mol Med Rep. 2016. PMID 27599661.
  • "Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.". Dis Markers. 2015. PMID 25922553.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ FRAT1 - Cronfa NCBI

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