FOXO3

FOXO3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K86, 2LQH, 2LQI, 2UZK
Dynodwyr
Cyfenwau	FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3
Dynodwyr allanol	OMIM: 602681 HomoloGene: 31039 GeneCards: FOXO3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein kinase binding • chromatin DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001144, GO:0001142, GO:0001143 mitochondrial transcription factor activity • transcription coregulator binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor binding Cydrannau o'r gell • bilen • nucleoplasm • cytosol • cytoplasm • cnewyllyn cell • mitocondria • mitochondrial outer membrane • mitochondrial matrix • GO:0009327 protein-containing complex Prosesau biolegol • initiation of primordial ovarian follicle growth • ovulation from ovarian follicle • GO:0009373 regulation of transcription, DNA-templated • antral ovarian follicle growth • positive regulation of erythrocyte differentiation • glucose homeostasis • DNA damage response, signal transduction by p53 class mediator • tumor necrosis factor-mediated signaling pathway • GO:1904489 regulation of reactive oxygen species metabolic process • transcription by RNA polymerase II • regulation of neural precursor cell proliferation • transcription, DNA-templated • neuronal stem cell population maintenance • positive regulation of neuron apoptotic process • oocyte maturation • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of apoptotic process • regulation of translation • negative regulation of canonical Wnt signaling pathway • GO:0097285 apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to oxidative stress • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of reactive oxygen species biosynthetic process • brain morphogenesis • GO:0010260 heneiddio • negative regulation of neuron differentiation • cellular response to hypoxia • response to water-immersion restraint stress • response to nutrient levels • cellular response to amyloid-beta • cellular response to corticosterone stimulus • positive regulation of endothelial cell apoptotic process • positive regulation of hydrogen peroxide-mediated programmed cell death • response to dexamethasone • cellular response to nerve growth factor stimulus • cellular response to glucose stimulus • anatomical structure morphogenesis • cytokine-mediated signaling pathway • mitochondrial transcription • negative regulation of cell migration • GO:1901047 insulin receptor signaling pathway • positive regulation of autophagy • positive regulation of muscle atrophy • response to starvation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2309	n/a
Ensembl	ENSG00000118689	n/a
UniProt	O43524	n/a
RefSeq (mRNA)	NM_001455 NM_201559	n/a
RefSeq (protein)	NP_001446 NP_963853	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXO3 yw FOXO3 a elwir hefyd yn Forkhead box O3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXO3.

• "Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population. ". PLoS One. 2017. PMID 29220389.
• "An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case-case-control study. ". BMC Med Genet. 2017. PMID 29141605.
• "Investigation of FoxO3 dynamics during erythroblast development in β-thalassemia major. ". PLoS One. 2017. PMID 29099866.
• "Protein kinase C downregulation induces senescence via FoxO3a inhibition in HCT116 and HEK293 cells. ". Biochem Biophys Res Commun. 2017. PMID 28989024.
• "Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients.". Am J Hematol. 2017. PMID 28699185.