FGF1

FGF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Dynodwyr
Cyfenwau	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
Dynodwyr allanol	OMIM: 131220 HomoloGene: 625 GeneCards: FGF1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• S100 protein binding; • GO:0001948, GO:0016582 protein binding; • growth factor activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • fibroblast growth factor receptor binding; • integrin binding; • 1-phosphatidylinositol-3-kinase activity; • heparin binding; • Hsp70 protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • extracellular region; • cell cortex; • nucleolus; • cnewyllyn cell; • extracellular space; • GO:0005578 extracellular matrix;
Prosesau biolegol	• cell differentiation; • cellular response to heat; • positive regulation of protein phosphorylation; • positive regulation of MAP kinase activity; • organ induction; • lung development; • positive regulation of epithelial cell proliferation; • anatomical structure morphogenesis; • GO:0010740 positive regulation of intracellular signal transduction; • branch elongation involved in ureteric bud branching; • positive regulation of angiogenesis; • MAPK cascade; • multicellular organism development; • mesonephric epithelium development; • angiogenesis; • regulation of endothelial cell chemotaxis to fibroblast growth factor; • positive regulation of cholesterol biosynthetic process; • cell population proliferation; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • positive regulation of sprouting angiogenesis; • fibroblast growth factor receptor signaling pathway; • positive regulation of cell population proliferation; • phosphatidylinositol-3-phosphate biosynthetic process; • regulation of endothelial tube morphogenesis; • positive regulation of cell migration; • positive regulation of endothelial cell migration; • activation of protein kinase B activity; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologau
	2246
	n/a
	ENSG00000113578
	n/a
	P05230
	n/a
NM_000800; NM_001144892; NM_001144934; NM_001144935; NM_001257205;
	NM_001257206; NM_001257207; NM_001257208; NM_001257209; NM_001257210; NM_001257211; NM_001257212; NM_033136; NM_033137; NM_001354955; NM_001354956; NM_001354957; NM_001354958; NM_001354959; NM_001354961; NM_001354963; NM_001354964; NM_001354951; NM_001354952; NM_001354953; NM_001354954; NM_001354962
	n/a
NP_000791; NP_001138364; NP_001138406; NP_001138407; NP_001244134;
	NP_001244135; NP_001244136; NP_001244137; NP_001244138; NP_001244139; NP_001244140; NP_001244141; NP_149127; NP_149128; NP_001341884; NP_001341885; NP_001341886; NP_001341887; NP_001341888; NP_001341890; NP_001341892; NP_001341893; NP_001341880; NP_001341881; NP_001341882; NP_001341883; NP_001341891
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF1 yw FGF1 a elwir hefyd yn Fibroblast growth factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF1.

AFGF
ECGF
FGFA
ECGFA
ECGFB
FGF-1
HBGF1
HBGF-1
GLIO703
ECGF-beta
FGF-alpha

Llyfryddiaeth

"Fibroblast Growth Factor 1-Transfected Adipose-Derived Mesenchymal Stem Cells Promote Angiogenic Proliferation. ". DNA Cell Biol. 2017. PMID 28281780.
"Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. ". J Pharm Sci. 2016. PMID 27019961.
"Identification of new FGF1 binding partners-Implications for its intracellular function. ". IUBMB Life. 2016. PMID 26840910.
"Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release. ". Biochemistry. 2016. PMID 26836284.
"Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls.". Endocr J. 2016. PMID 26806193.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FGF1 - Cronfa NCBI

[1]

[2]

FGF1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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