FES

FES
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93
Dynodwyr
Cyfenwau	FES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
Dynodwyr allanol	OMIM: 190030 HomoloGene: 37563 GeneCards: FES
EC number	2.7.10.2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • microtubule binding • immunoglobulin receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • phosphatidylinositol binding • ATP binding • lipid binding • protein tyrosine kinase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • bilen • focal adhesion • microtubule cytoskeleton • extrinsic component of cytoplasmic side of plasma membrane • cellbilen • cell junction • Cytosgerbwd • GO:0016023 cytoplasmic vesicle Prosesau biolegol • phosphorylation • regulation of vesicle-mediated transport • regulation of cell motility • multicellular organism development • chemotaxis • protein phosphorylation • regulation of cell adhesion • regulation of cell population proliferation • microtubule bundle formation • regulation of cell shape • positive regulation of neuron projection development • positive regulation of microtubule polymerization • peptidyl-tyrosine autophosphorylation • regulation of cell differentiation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • regulation of mast cell degranulation • cell population proliferation • innate immune response • positive regulation of actin cytoskeleton reorganization • positive regulation of myeloid cell differentiation • epidermal growth factor receptor signaling pathway • cell migration • centrosome cycle • cell adhesion • positive regulation of monocyte differentiation • cellular response to vitamin D Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2242	n/a
Ensembl	ENSG00000182511	n/a
UniProt	P07332	n/a
RefSeq (mRNA)	NM_001143783 NM_001143784 NM_001143785 NM_002005	n/a
RefSeq (protein)	NP_001137255 NP_001137256 NP_001137257 NP_001996	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FES yw FES a elwir hefyd yn Tyrosine-protein kinase Fes/Fps a FES proto-oncogene, tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FES.

• FPS

• "[Expression of c-fes gene in leukemia cells and its clinical significance]. ". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009. PMID 20030920.
• "Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. ". Biochemistry. 2009. PMID 19382747.
• "Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells. ". Int J Oncol. 2009. PMID 19082481.
• "Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer. ". Genes Chromosomes Cancer. 2009. PMID 19051325.
• "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.". J Biol Chem. 2006. PMID 16455651.