FECH

FECH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4MK4, 1HRK, 2HRC, 2HRE, 2PNJ, 2PO5, 2PO7, 2QD1, 2QD2, 2QD3, 2QD4, 2QD5, 3AQI, 3HCN, 3HCO, 3HCP, 3HCR, 3W1W, 4F4D, 4KLA, 4KLC, 4KLR, 4KMM
Dynodwyr
Cyfenwau	FECH, EPP, FCE, ferrochelatase, EPP1
Dynodwyr allanol	OMIM: 612386 HomoloGene: 113 GeneCards: FECH
EC number	4.98.1.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron-sulfur cluster binding • metal ion binding • GO:0001948, GO:0016582 protein binding • ferrochelatase activity • lyase activity • ferrous iron binding • 2 iron, 2 sulfur cluster binding Cydrannau o'r gell • bilen • mitochondrial matrix • mitochondrial inner membrane • mitocondria Prosesau biolegol • response to platinum ion • response to light stimulus • response to metal ion • response to arsenic-containing substance • generation of precursor metabolites and energy • cellular response to dexamethasone stimulus • porphyrin-containing compound biosynthetic process • response to lead ion • protoporphyrinogen IX metabolic process • response to insecticide • response to methylmercury • response to ethanol • heme biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2235	n/a
Ensembl	ENSG00000066926	n/a
UniProt	P22830	n/a
RefSeq (mRNA)	NM_000140 NM_001012515 NM_001371094 NM_001371095 NM_001374778	n/a
RefSeq (protein)	NP_000131 NP_001012533 NP_001358023 NP_001358024 NP_001361707	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FECH yw FECH a elwir hefyd yn Ferrochelatase, mitochondrial a Ferrochelatase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FECH.

• EPP
• FCE

• "Human Ferrochelatase: Insights for the Mechanism of Ferrous Iron Approaching Protoporphyrin IX by QM/MM and QTCP Free Energy Studies. ". J Chem Inf Model. 2016. PMID 27801584.
• "A Novel Mutation in the FECH Gene in a Czech Family with Erythropoietic Protoporphyria and a Population Study of IVS3-48C Variant Contributing to the Disease. ". Folia Biol (Praha). 2015. PMID 26789144.
• "Incomplete erythropoietic protoporphyria caused by a splice site modulator homozygous IVS3-48C polymorphism in the ferrochelatase gene. ". Br J Dermatol. 2016. PMID 26280465.
• "Antisense oligonucleotide-based therapy in human erythropoietic protoporphyria. ". Am J Hum Genet. 2014. PMID 24680888.
• "New mutation identified in two sisters with adult-onset erythropoietic protoporphyria.". Clin Exp Dermatol. 2013. PMID 23600449.