EXOSC4

EXOSC4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2NN6
Dynodwyr
Cyfenwau	EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A, Exosome component 4
Dynodwyr allanol	OMIM: 606491 HomoloGene: 6017 GeneCards: EXOSC4
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • exoribonuclease activity; • 3'-5'-exoribonuclease activity; • RNA binding; • mRNA 3'-UTR AU-rich region binding;
Cydrannau o'r gell	• cytoplasmic exosome (RNase complex); • nuclear exosome (RNase complex); • cytoplasm; • exosome (RNase complex); • nucleolus; • cnewyllyn cell; • nucleoplasm; • cytosol; • intermediate filament cytoskeleton;
Prosesau biolegol	• defense response to virus; • rRNA 3'-end processing; • rRNA catabolic process; • polyadenylation-dependent snoRNA 3'-end processing; • U4 snRNA 3'-end processing; • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; • positive regulation of cell growth; • nuclear-transcribed mRNA catabolic process; • DNA deamination; • maturation of 5.8S rRNA; • regulation of mRNA stability; • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance; • exonucleolytic catabolism of deadenylated mRNA; • histone mRNA catabolic process; • rRNA processing; • RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologau
	54512
	n/a
	ENSG00000178896
	n/a
	Q9NPD3
	n/a
	NM_019037
	n/a
	NP_061910
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC4 yw EXOSC4 a elwir hefyd yn Exosome complex component RRP41 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q24.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC4.

SKI6
p12A
RRP41
Ski6p
RRP41A
Rrp41p
hRrp41p

Llyfryddiaeth

"Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. ". Arthritis Res. 2002. PMID 11879549.
"Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. ". Proc Natl Acad Sci U S A. 2010. PMID 20368444.
"Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. ". RNA. 2006. PMID 16912217.
"Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. ". Nature. 2014. PMID 25043052.
"A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination.". Nucleic Acids Res. 2010. PMID 20699273.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EXOSC4 - Cronfa NCBI

[1]

[2]

EXOSC4

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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