ERBB4

ERBB4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Dynodwyr
Cyfenwau	ERBB4, ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4
Dynodwyr allanol	OMIM: 600543 HomoloGene: 21084 GeneCards: ERBB4
EC number	2.7.10.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • epidermal growth factor receptor binding • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity Cydrannau o'r gell • integral component of membrane • cytosol • bilen • receptor complex • cellbilen • nucleoplasm • extracellular region • mitochondrial matrix • basolateral plasma membrane • mitocondria • cnewyllyn cell • postsynaptic membrane • glutamatergic synapse • GABA-ergic synapse • integral component of presynaptic membrane • integral component of postsynaptic density membrane • cytoplasm • integral component of plasma membrane • basal plasma membrane Prosesau biolegol • mitochondrial fragmentation involved in apoptotic process • negative regulation of neuron migration • cell fate commitment • positive regulation of protein phosphorylation • regulation of cell migration • GO:0009373 regulation of transcription, DNA-templated • olfactory bulb interneuron differentiation • embryonic pattern specification • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • central nervous system morphogenesis • mammary gland alveolus development • transcription, DNA-templated • nervous system development • mammary gland epithelial cell differentiation • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • development of the heart • protein phosphorylation • positive regulation of cardiac muscle cell proliferation • neural crest cell migration • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein localization to cell surface • protein autophosphorylation • cardiac muscle tissue regeneration • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • lactation • cell population proliferation • cell migration • GO:0072468 signal transduction • negative regulation of cell population proliferation • GO:0097285 apoptotic process • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine autophosphorylation • positive regulation of cell population proliferation • positive regulation of apoptotic process • regulation of cell motility • negative regulation of apoptotic process • cellular response to epidermal growth factor stimulus • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of protein kinase B signaling • positive regulation of receptor signaling pathway via JAK-STAT • synapse assembly • negative regulation of signal transduction • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2066	n/a
Ensembl	ENSG00000178568	n/a
UniProt	Q15303	n/a
RefSeq (mRNA)	NM_001042599 NM_005235	n/a
RefSeq (protein)	NP_001036064 NP_005226	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBB4 yw ERBB4 a elwir hefyd yn Receptor tyrosine-protein kinase erbB-4 ac Erb-b2 receptor tyrosine kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q34.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBB4.

• HER4
• ALS19
• p180erbB4

• "Association between ErbB4 single nucleotide polymorphisms and susceptibility to schizophrenia: A meta-analysis of case-control studies. ". Medicine (Baltimore). 2017. PMID 28225484.
• "ERBB4 Expression in Ovarian Serous Carcinoma Resistant to Platinum-Based Therapy. ". Cancer Control. 2017. PMID 28178720.
• "ERBB4 gene polymorphisms and the risk of prostate cancer in a sample of Iranian Population. ". Cell Mol Biol (Noisy-le-grand). 2016. PMID 27609473.
• "ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells. ". Stem Cells. 2016. PMID 27324647.
• "Analysis of regulatory mechanism after ErbB4 gene mutation based on local modeling methodology.". Genet Mol Res. 2016. PMID 27323039.