EPRS

EPRS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FYJ, 4HVC, 4K86, 4K87, 4K88, 5A34, 5BMU, 5A1N, 5A5H
Dynodwyr
Cyfenwau	EPRS1, EARS, GLUPRORS, PARS, QARS, QPRS, PIG32, glutamyl-prolyl-tRNA synthetase, HLD15, glutamyl-prolyl-tRNA synthetase 1, EPRS
Dynodwyr allanol	OMIM: 138295 HomoloGene: 5870 GeneCards: EPRS1
EC number	6.1.1.17 6.1.1.15, 6.1.1.17
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • RNA stem-loop binding • ATP binding • catalytic activity • ligase activity • aminoacyl-tRNA ligase activity • GTPase binding • RNA binding • glutamate-tRNA ligase activity • proline-tRNA ligase activity • zinc ion binding • protein homodimerization activity • metal ion binding • identical protein binding Cydrannau o'r gell • bilen • GAIT complex • cytoplasm • aminoacyl-tRNA synthetase multienzyme complex • cytosol • cellbilen • ribonucleoprotein complex Prosesau biolegol • regulation of translation • tRNA aminoacylation • metabolaeth • protein biosynthesis • tRNA aminoacylation for protein translation • negative regulation of translation • cellular response to interferon-gamma • glutamyl-tRNA aminoacylation • prolyl-tRNA aminoacylation • cellular response to insulin stimulus • long-chain fatty acid import into cell • GO:0034622 protein-containing complex assembly • regulation of long-chain fatty acid import into cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2058	n/a
Ensembl	ENSG00000136628	n/a
UniProt	P07814	n/a
RefSeq (mRNA)	NM_004446	n/a
RefSeq (protein)	NP_004437	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPRS yw EPRS a elwir hefyd yn Glutamyl-prolyl-tRNA synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q41.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPRS.

• "Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. ". Mol Cell. 2009. PMID 19647514.
• "WHEP domains direct noncanonical function of glutamyl-Prolyl tRNA synthetase in translational control of gene expression. ". Mol Cell. 2008. PMID 18374644.
• "Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. ". Biochemistry. 2000. PMID 11123902.
• "The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes. ". Nucleic Acids Res. 1988. PMID 3290852.
• "The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42.". Hum Genet. 1990. PMID 2227938.