ELK1

ELK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DUX
Dynodwyr
Cyfenwau	ELK1, ETS transcription factor, ETS transcription factor ELK1
Dynodwyr allanol	OMIM: 311040 HomoloGene: 3832 GeneCards: ELK1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • double-stranded DNA binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • axon terminus; • nucleoplasm; • soma; • dendrite; • mitocondria; • cnewyllyn cell;
Prosesau biolegol	• cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • response to light stimulus; • cellular response to testosterone stimulus; • response to fibroblast growth factor; • positive regulation of neuron death; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • cellular response to gamma radiation; • cellular response to lipid; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	2002
	n/a
	ENSG00000126767
	n/a
	P19419
	n/a
	NM_005229; NM_001114123; NM_001257168
	n/a
	NP_001107595; NP_001244097; NP_005220
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ELK1 yw ELK1 a elwir hefyd yn ELK1, ETS transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp11.23.^[2]

Llyfryddiaeth

"Silodosin inhibits prostate cancer cell growth via ELK1 inactivation and enhances the cytotoxic activity of gemcitabine. ". Prostate. 2016. PMID 26864615.
"Downregulated protein expression of transcriptional activator ELK-1 in atrial myocardium of chronic AF patients. ". Int J Clin Exp Pathol. 2015. PMID 26617947.
"ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression. ". Oncotarget. 2015. PMID 26342199.
"Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene. ". Cell Rep. 2013. PMID 23871667.
"Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features.". Breast. 2013. PMID 23127278.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ELK1 - Cronfa NCBI

[1]

[2]

ELK1

Llyfryddiaeth

Cyfeiriadau

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