ELF5

ELF5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WWX
Dynodwyr
Cyfenwau	ELF5, ESE2, E74 like ETS transcription factor 5
Dynodwyr allanol	OMIM: 605169 HomoloGene: 7702 GeneCards: ELF5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • ectodermal cell fate commitment • negative regulation of cell differentiation • cell differentiation • ectoderm development • cell population proliferation • GO:0009373 regulation of transcription, DNA-templated • somatic stem cell population maintenance • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • mammary gland epithelial cell differentiation • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2001	n/a
Ensembl	ENSG00000135374	n/a
UniProt	Q9UKW6	n/a
RefSeq (mRNA)	NM_198381 NM_001243080 NM_001243081 NM_001422	n/a
RefSeq (protein)	NP_001230009 NP_001230010 NP_001413 NP_938195	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ELF5 yw ELF5 a elwir hefyd yn E74 like ETS transcription factor 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ELF5.

• ESE2

• "ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348. ". Exp Cell Res. 2017. PMID 28800960.
• "ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells. ". Oncol Rep. 2017. PMID 28184931.
• "ELF5 isoform expression is tissue-specific and significantly altered in cancer. ". Breast Cancer Res. 2016. PMID 26738740.
• "Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population. ". J Microbiol Immunol Infect. 2016. PMID 25648666.
• "Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.". PLoS One. 2015. PMID 25629735.