EIF4E

EIF4E
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IPB, 1IPC, 1WKW, 2GPQ, 2V8W, 2V8X, 2V8Y, 2W97, 3AM7, 3TF2, 3U7X, 4AZA, 4BEA, 4DT6, 4DUM, 4TPW, 4TQB, 4TQC, 4UED, 5ABI
Dynodwyr
Cyfenwau	EIF4E, eukaryotic translation initiation factor 4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
Dynodwyr allanol	OMIM: 133440 HomoloGene: 123817 GeneCards: EIF4E
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • translation initiation factor activity • eukaryotic initiation factor 4G binding • GO:0001948, GO:0016582 protein binding • enzyme binding • RNA cap binding • RNA 7-methylguanosine cap binding • RNA binding • translation regulator activity Cydrannau o'r gell • cytoplasm • chromatoid body • RISC complex • P-body • mRNA cap binding complex • perinuclear region of cytoplasm • cytoplasmic stress granule • eukaryotic translation initiation factor 4F complex • extracellular exosome • cytosol • cytoplasmic ribonucleoprotein granule • GO:0009327 protein-containing complex • postsynapse • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • nuclear-transcribed mRNA poly(A) tail shortening • negative regulation of translation • negative regulation of neuron differentiation • lung development • G1 phase • positive regulation of mitotic cell cycle • behavioral fear response • mRNA export from nucleus • stem cell population maintenance • translational initiation • GO:0022415 viral process • regulation of translation • RNA export from nucleus • protein biosynthesis • negative regulation of autophagy • cellular response to dexamethasone stimulus • G1/S transition of mitotic cell cycle • regulation of translation at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1977	n/a
Ensembl	ENSG00000151247	n/a
UniProt	P06730	n/a
RefSeq (mRNA)	NM_001130678 NM_001130679 NM_001968 NM_001331017	n/a
RefSeq (protein)	NP_001124150 NP_001124151 NP_001317946 NP_001959	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4E yw EIF4E a elwir hefyd yn Eukaryotic translation initiation factor 4E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q23.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4E.

• "Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection. ". Virology. 2017. PMID 28843814.
• "A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery. ". RNA. 2017. PMID 28325843.
• "Water-Bridge Mediates Recognition of mRNA Cap in eIF4E. ". Structure. 2017. PMID 27916520.
• "Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, growth and survival of human hepatocellular carcinoma. ". Biomed Pharmacother. 2016. PMID 27662474.
• "Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma.". J Cancer Res Clin Oncol. 2016. PMID 27601163.