EIF4A3

EIF4A3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HXY, 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7, 4C9B
Dynodwyr
Cyfenwau	EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, eIF4A-III, eIF-4A-III
Dynodwyr allanol	OMIM: 608546 HomoloGene: 5602 GeneCards: EIF4A3
EC number	3.6.4.13
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • selenocysteine insertion sequence binding • GO:0008026 helicase activity • poly(A) binding • RNA stem-loop binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • ribonucleoprotein complex binding • hydrolase activity • ATP binding • mRNA binding • RNA binding • translation regulator activity Cydrannau o'r gell • cytoplasm • cytosol • nuclear speck • catalytic step 2 spliceosome • bilen • exon-exon junction complex • soma • dendrite • spliceosomal complex • cnewyllyn cell • nucleoplasm • nucleolus • glutamatergic synapse • postsynaptic cytosol • ribonucleoprotein complex • U2-type catalytic step 1 spliceosome Prosesau biolegol • nuclear-transcribed mRNA poly(A) tail shortening • mRNA transport • negative regulation of translation • associative learning • GO:1904578 response to organic cyclic compound • regulation of mRNA binding • mRNA processing • positive regulation of translation • negative regulation of gene expression • negative regulation of excitatory postsynaptic potential • cellular response to brain-derived neurotrophic factor stimulus • cellular response to selenite ion • exploration behavior • RNA secondary structure unwinding • RNA splicing • rRNA processing • embryonic cranial skeleton morphogenesis • negative regulation of selenocysteine insertion sequence binding • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • regulation of translation • negative regulation of selenocysteine incorporation • mRNA splicing, via spliceosome • RNA export from nucleus • termination of RNA polymerase II transcription • mRNA export from nucleus • mRNA 3'-end processing • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of mRNA splicing, via spliceosome • GO:0015915 transport • regulation of translation at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9775	n/a
Ensembl	ENSG00000141543	n/a
UniProt	P38919	n/a
RefSeq (mRNA)	NM_014740	n/a
RefSeq (protein)	NP_055555	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4A3 yw EIF4A3 a elwir hefyd yn Eukaryotic translation initiation factor 4A3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4A3.

• "Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. ". Cancer Lett. 2002. PMID 12127692.
• "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. ". Biochem Biophys Res Commun. 2000. PMID 10623621.
• "The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication. ". Virology. 2016. PMID 26773380.
• "eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. ". Nat Struct Mol Biol. 2004. PMID 15034551.
• "A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay.". Proc Natl Acad Sci U S A. 2004. PMID 15024115.