EGR1

EGR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R2A, 4R2C, 4R2D, 4X9J
Dynodwyr
Cyfenwau	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response 1
Dynodwyr allanol	OMIM: 128990 HomoloGene: 56394 GeneCards: EGR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • metal ion binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • nucleic acid binding • hemi-methylated DNA-binding • double-stranded methylated DNA binding • zinc ion binding • promoter-specific chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytoplasm Prosesau biolegol • regulation of apoptotic process • cellular response to organic substance • GO:0009373 regulation of transcription, DNA-templated • glomerular mesangial cell proliferation • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • transcription by RNA polymerase II • BMP signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to insulin • interleukin-1-mediated signaling pathway • cellular response to mycophenolic acid • T cell differentiation • type I interferon signaling pathway • positive regulation of glomerular metanephric mesangial cell proliferation • cellular response to gamma radiation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • skeletal muscle cell differentiation • cellular response to heparin • regulation of protein sumoylation • negative regulation of canonical Wnt signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to interleukin-8 • response to hypoxia • response to ischemia • estrous cycle • positive regulation of hormone biosynthetic process • regulation of progesterone biosynthetic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • circadian regulation of gene expression • locomotor rhythm • proses rythmig • circadian temperature homeostasis • positive regulation of neuron death • positive regulation of tau-protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1958	n/a
Ensembl	ENSG00000120738	n/a
UniProt	P18146	n/a
RefSeq (mRNA)	NM_001964	n/a
RefSeq (protein)	NP_001955	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EGR1 yw EGR1 a elwir hefyd yn Early growth response 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EGR1.

• "Thermodynamic Additivity for Impacts of Base-Pair Substitutions on Association of the Egr-1 Zinc-Finger Protein with DNA. ". Biochemistry. 2016. PMID 27933778.
• "Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity. ". Stem Cells Dev. 2016. PMID 26988763.
• "EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types. ". BMC Musculoskelet Disord. 2016. PMID 26975996.
• "Epigallocatechin-3-gallate inhibits transforming-growth-factor-β1-induced collagen synthesis by suppressing early growth response-1 in human buccal mucosal fibroblasts. ". J Formos Med Assoc. 2017. PMID 26922429.
• "Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension.". J Heart Lung Transplant. 2016. PMID 26774383.