EGLN1

EGLN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G19, 2G1M, 2HBT, 2HBU, 2Y33, 2Y34, 3HQR, 3HQU, 3OUH, 3OUI, 3OUJ, 4BQW, 4BQX, 4BQY, 4JZR, 4KBZ, 4UWD, 5A3U
Dynodwyr
Cyfenwau	EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6, HALAH, egl-9 family hypoxia inducible factor 1
Dynodwyr allanol	OMIM: 606425 HomoloGene: 56936 GeneCards: EGLN1
EC number	1.14.11.29
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 2-oxoglutarate-dependent dioxygenase activity • iron ion binding • L-ascorbic acid binding • dioxygenase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • peptidyl-proline dioxygenase activity • enzyme binding • oxidoreductase activity • peptidyl-proline 4-dioxygenase activity • ferrous iron binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • cytosol • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse Prosesau biolegol • response to hypoxia • heart trabecula formation • ventricular septum morphogenesis • labyrinthine layer development • response to nitric oxide • peptidyl-proline hydroxylation to 4-hydroxy-L-proline • cardiac muscle tissue morphogenesis • regulation of angiogenesis • negative regulation of DNA-binding transcription factor activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of cyclic-nucleotide phosphodiesterase activity • oxygen homeostasis • regulation of neuron death • cellular iron ion homeostasis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of postsynapse organization • regulation of protein catabolic process at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54583	n/a
Ensembl	ENSG00000135766	n/a
UniProt	Q9GZT9	n/a
RefSeq (mRNA)	NM_022051 NM_001377260 NM_001377261	n/a
RefSeq (protein)	NP_071334	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EGLN1 yw EGLN1 a elwir hefyd yn Egl-9 family hypoxia inducible factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q42.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EGLN1.

• "Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation. ". Mol Biol Evol. 2013. PMID 23666208.
• "Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing. ". Int J Cancer. 2013. PMID 23225569.
• "Ultrasound-targeted microbubble destruction (UTMD) assisted delivery of shRNA against PHD2 into H9C2 cells. ". PLoS One. 2015. PMID 26267649.
• "Tumor PHD2 expression is correlated with clinical features and prognosis of patients with HCC receiving liver resection. ". Medicine (Baltimore). 2014. PMID 25546659.
• "Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium.". Circ Res. 2013. PMID 23694817.