DRD2

DRD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 6CM4
Dynodwyr
Cyfenwau	DRD2, D2DR, D2R, dopamine receptor D2
Dynodwyr allanol	OMIM: 126450 HomoloGene: 22561 GeneCards: DRD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • potassium channel regulator activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • identical protein binding • dopamine neurotransmitter receptor activity • G protein-coupled receptor activity • GO:0001948, GO:0016582 protein binding • signal transducer activity • adrenergic receptor activity • dopamine binding • signaling receptor binding • ionotropic glutamate receptor binding • protein heterodimerization activity Cydrannau o'r gell • GO:0016023 cytoplasmic vesicle • sperm flagellum • endocytic vesicle • acrosomal vesicle • dendritic spine • synaptic vesicle membrane • perikaryon • cellbilen • dendrite • ciliary membrane • axon terminus • integral component of membrane • GO:0097483, GO:0097481 postsynaptic density • bilen • lateral plasma membrane • axon • intracellular anatomical structure • non-motile cilium • integral component of plasma membrane • dopaminergic synapse • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of presynaptic membrane Prosesau biolegol • negative regulation of cell population proliferation • temperature homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenohypophysis development • circadian regulation of gene expression • response to toxic substance • regulation of dopamine secretion • adwaith i gocên • response to amphetamine • sensory perception of smell • locomotory behavior • positive regulation of urine volume • response to ethanol • axonogenesis • response to inactivity • phospholipase C-activating dopamine receptor signaling pathway • modulation of chemical synaptic transmission • grooming behavior • negative regulation of protein kinase B signaling • associative learning • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • regulation of synaptic transmission, GABAergic • positive regulation of dopamine uptake involved in synaptic transmission • GO:0072468 signal transduction • Wnt • adult walking behavior • branching morphogenesis of a nerve • negative regulation of cytosolic calcium ion concentration • negative regulation of innate immune response • regulation of phosphoprotein phosphatase activity • acid secretion • feeding behavior • positive regulation of G protein-coupled receptor signaling pathway • response to axon injury • striatum development • synaptic transmission, dopaminergic • nervous system process involved in regulation of systemic arterial blood pressure • peristalsis • regulation of long-term neuronal synaptic plasticity • activation of protein kinase activity • positive regulation of growth hormone secretion • regulation of sodium ion transport • forebrain development • response to light stimulus • orbitofrontal cortex development • prepulse inhibition • response to morphine • response to iron ion • positive regulation of ERK1 and ERK2 cascade • long-term memory • positive regulation of renal sodium excretion • negative regulation of insulin secretion • neuron-neuron synaptic transmission • GO:0007243 intracellular signal transduction • auditory behavior • behavioral response to ethanol • regulation of heart rate • adenylate cyclase-activating adrenergic receptor signaling pathway • positive regulation of cytokinesis • regulation of potassium ion transport • pigmentation • cellular calcium ion homeostasis • dopamine metabolic process • response to nicotine • regulation of MAPK cascade • response to histamine • negative regulation of synaptic transmission, glutamatergic • response to hypoxia • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of protein secretion • synapse assembly • regulation of locomotion involved in locomotory behavior • dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • startle response • positive regulation of receptor internalization • GO:0034613 protein localization • arachidonic acid secretion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • G protein-coupled receptor internalization • positive regulation of multicellular organism growth • positive regulation of long-term synaptic potentiation • negative regulation of dopamine secretion • adult behavior • cerebral cortex GABAergic interneuron migration • regulation of synapse structural plasticity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • visual learning • negative regulation of cell migration • behavioral response to cocaine • positive regulation of neuroblast proliferation • negative regulation of blood pressure • release of sequestered calcium ion into cytosol • negative regulation of voltage-gated calcium channel activity • G protein-coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • excitatory postsynaptic potential • GO:0033128 negative regulation of protein phosphorylation • autophagy • positive regulation of neurogenesis • negative regulation of cell death • drinking behavior • adrenergic receptor signaling pathway • regulation of neurotransmitter uptake • postsynaptic modulation of chemical synaptic transmission • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1813	n/a
Ensembl	ENSG00000149295	n/a
UniProt	P14416	n/a
RefSeq (mRNA)	NM_016574 NM_000795	n/a
RefSeq (protein)	NP_000786 NP_057658 NP_000786.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DRD2 yw DRD2 a elwir hefyd yn Dopamine receptor D2, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DRD2.

• D2R
• D2DR

• "The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum. ". Transl Psychiatry. 2017. PMID 28398340.
• "Association of the dopamine D2 receptor rs1800497 polymorphism and eating behavior in Chilean children. ". Nutrition. 2017. PMID 28241982.
• "DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia. ". Transl Psychiatry. 2017. PMID 28094815.
• "Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells. ". J Biol Chem. 2017. PMID 27920206.
• "Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders.". Acta Neuropathol Commun. 2016. PMID 27908295.