DNAJB1

DNAJB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HDJ, 2QLD, 3AGX, 3AGY, 3AGZ, 4WB7
Dynodwyr
Cyfenwau	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1, DnaJ heat shock protein family (Hsp40) member B1
Dynodwyr allanol	OMIM: 604572 HomoloGene: 55957 GeneCards: DNAJB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • unfolded protein binding • ATPase binding • Hsp70 protein binding • chaperone binding • GO:0001948, GO:0016582 protein binding • ATPase activator activity • GO:0001106 transcription corepressor activity • cadherin binding Cydrannau o'r gell • cytosol • nucleolus • extracellular exosome • cnewyllyn cell • nucleoplasm • cytoplasm • GO:0097483, GO:0097481 postsynaptic density • soma • dendritic spine • sperm head • postsynapse • glutamatergic synapse Prosesau biolegol • regulation of cellular response to heat • response to unfolded protein • positive regulation of ATP-dependent activity • protein folding • chaperone cofactor-dependent protein refolding • negative regulation of inclusion body assembly • negative regulation of transcription from RNA polymerase II promoter in response to stress • GO:1901227 negative regulation of transcription by RNA polymerase II • forebrain development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3337	n/a
Ensembl	ENSG00000132002	n/a
UniProt	P25685	n/a
RefSeq (mRNA)	NM_001313964 NM_001300914 NM_006145	n/a
RefSeq (protein)	NP_001287843 NP_001300893 NP_006136	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNAJB1 yw DNAJB1 a elwir hefyd yn DnaJ homolog subfamily B member 1 a DnaJ heat shock protein family (Hsp40) member B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNAJB1.

• "Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. ". Sci Rep. 2016. PMID 26750153.
• "Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. ". Arthritis Rheum. 2013. PMID 23400395.
• "Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells. ". Int J Mol Med. 2012. PMID 22075554.
• "Purification, crystallization and preliminary X-ray crystallographic analysis of the human heat-shock protein 40 Hdj1 and its C-terminal peptide-binding domain. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID 21139202.
• "The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1.". BMC Struct Biol. 2008. PMID 18211704.