DHX9

DHX9
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3LLM, 3VYX, 3VYY
Dynodwyr
Cyfenwau	DHX9, DDX9, LKP, NDH2, NDHII, RHA, RNA Helicase A, DEAH-box helicase 9, DExH-box helicase 9
Dynodwyr allanol	OMIM: 603115 HomoloGene: 1039 GeneCards: DHX9
EC number	3.6.4.13
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• RNA helicase activity; • nucleotide binding; • GO:0008026 helicase activity; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • hydrolase activity; • RNA binding; • DNA binding; • single-stranded DNA binding; • double-stranded RNA binding; • single-stranded RNA binding; • nucleoside-triphosphatase activity; • chromatin DNA binding; • GO:0033681 3'-5' DNA/RNA helicase activity; • GO:0034459 3'-5' RNA helicase activity; • triplex DNA binding; • nucleoside-triphosphate diphosphatase activity; • importin-alpha family protein binding; • single-stranded 3'-5' DNA helicase activity; • siRNA binding; • mRNA binding; • RNA stem-loop binding; • polysome binding; • promoter-specific chromatin binding; • RNA polymerase II complex binding; • regulatory region RNA binding; • GO:0001104 transcription coregulator activity; • GO:0001105 transcription coactivator activity; • DNA replication origin binding; • double-stranded DNA binding; • GO:0004003 DNA helicase activity; • ATP binding; • ATPase activity; • RNA polymerase binding; • GO:0043140 3'-5' DNA helicase activity; • RISC complex binding; • sequence-specific mRNA binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• CRD-mediated mRNA stability complex; • cytosol; • centrosome; • bilen; • cytoplasmic ribonucleoprotein granule; • cnewyllyn cell; • nucleolus; • perichromatin fibrils; • cytoplasm; • nuclear stress granule; • nuclear body; • polysomal ribosome; • polysome; • actin cytoskeleton; • RISC-loading complex; • nucleoplasm; • microtubule organizing center; • Cytosgerbwd; • GO:0009327 protein-containing complex; • ribonucleoprotein complex;
Prosesau biolegol	• CRD-mediated mRNA stabilization; • mRNA splicing, via spliceosome; • GO:0033168, GO:0036404, GO:1902360 RNA processing; • proses rythmig; • protein localization to cytoplasmic stress granule; • osteoblast differentiation; • positive regulation of type I interferon production; • RNA secondary structure unwinding; • GO:1900404 positive regulation of DNA repair; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of response to cytokine stimulus; • cellular response to exogenous dsRNA; • alternative mRNA splicing, via spliceosome; • DNA-templated viral transcription; • positive regulation of viral transcription; • positive regulation of viral translation; • positive regulation of cytoplasmic translation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • DNA duplex unwinding; • positive regulation of DNA replication; • positive regulation of fibroblast proliferation; • regulation of mRNA processing; • positive regulation of NF-kappaB transcription factor activity; • cellular response to tumor necrosis factor; • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; • regulation of cytoplasmic translation; • positive regulation of interleukin-18 production; • G-quadruplex DNA unwinding; • positive regulation of innate immune response; • positive regulation of RNA export from nucleus; • regulation of defense response to virus by host; • positive regulation of inflammatory response; • pyroptosis; • GO:0035087, GO:0035280, GO:0070923 small RNA loading onto RISC; • positive regulation of polysome binding; • GO:1905618 positive regulation of gene silencing by miRNA; • proses y system imiwnedd; • DNA replication; • transcription, DNA-templated; • DNA-templated transcription, termination; • GO:0009373 regulation of transcription, DNA-templated; • mRNA processing; • regulation of translation; • GO:0015915 transport; • inflammatory response; • RNA splicing; • gene silencing; • innate immune response; • mRNA transport;
	Sources:Amigo / QuickGO
Orthologau
	1660
	n/a
	ENSG00000135829
	n/a
	Q08211
	n/a
	NM_001357; NM_030588
	n/a
	NP_001348
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DHX9 yw DHX9 a elwir hefyd yn DExH-box helicase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DHX9.

LKP
RHA
DDX9
NDH2
NDHII

Llyfryddiaeth

"The RNA helicase A in malignant transformation. ". Oncotarget. 2016. PMID 26885691.
"Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. ". Oncotarget. 2015. PMID 26450900.
"Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA. ". Biochim Biophys Acta. 2014. PMID 25149208.
"Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell. ". Biochim Biophys Acta. 2014. PMID 24726449.
"Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism.". PLoS One. 2013. PMID 24223160.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DHX9 - Cronfa NCBI

[1]

[2]

DHX9

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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