CSNK2A1

CSNK2A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JWH, 1NA7, 1PJK, 2PVR, 2ZJW, 3AMY, 3AT2, 3AT3, 3AT4, 3AXW, 3BQC, 3C13, 3FWQ, 3H30, 3JUH, 3MB6, 3MB7, 3NGA, 3NSZ, 3OWJ, 3OWK, 3OWL, 3PE1, 3PE2, 3PE4, 3Q04, 3Q9W, 3Q9X, 3Q9Y, 3Q9Z, 3QA0, 3R0T, 3RPS, 3TAX, 3U4U, 3U87, 3U9C, 3W8L, 3WAR, 3WIK, 3WIL, 3WOW, 4DGL, 4FBX, 4GRB, 4GUB, 4GYW, 4GYY, 4GZ3, 4IB5, 4KWP, 4MD7, 4MD8, 4MD9, 4NH1, 4RLL, 4UB7, 4UBA, 5CQU, 5CQW, 5H8G, 5H8B, 5H8E, 5CLP, 5CSH, 5CVH, 5CS6, 5CU6, 5B0X
Dynodwyr
Cyfenwau	CSNK2A1, Csnk2a1, Csnk2a1-rs4, CK2A1, CKII, CSNK2A3, casein kinase 2 alpha 1, OCNDS, Cka1, Cka2
Dynodwyr allanol	OMIM: 115440 HomoloGene: 90874 GeneCards: CSNK2A1
EC number	2.7.11.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • Hsp90 protein binding • protein kinase activity • protein N-terminus binding • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • kinase activity • beta-catenin binding • protein phosphatase regulator activity • ribonucleoprotein complex binding • identical protein binding Cydrannau o'r gell • NuRD complex • cytosol • Sin3 complex • PcG protein complex • cnewyllyn cell • nucleoplasm • protein kinase CK2 complex • chromatin • cytoplasm • cellbilen Prosesau biolegol • chaperone-mediated protein folding • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0009373 regulation of transcription, DNA-templated • GO:1903364 positive regulation of protein catabolic process • phosphorylation • proses rythmig • Wnt • transcription, DNA-templated • positive regulation of Wnt signaling pathway • protein phosphorylation • positive regulation of cell growth • positive regulation of cell population proliferation • cell cycle • GO:0072468 signal transduction • GO:0097285 apoptotic process • regulation of signal transduction by p53 class mediator • protein folding • phosphatidylcholine biosynthetic process • macroautophagy • peptidyl-threonine phosphorylation • cerebral cortex development • response to testosterone • protein autophosphorylation • liver regeneration • regulation of protein localization to plasma membrane • regulation of chromosome separation • GO:0035404 peptidyl-serine phosphorylation • negative regulation of ubiquitin-dependent protein catabolic process • negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1457	n/a
Ensembl	ENSG00000101266	n/a
UniProt	P68400 Q5U5J2	n/a
RefSeq (mRNA)	NM_001895 NM_177559 NM_177560 NM_001362770 NM_001362771	n/a
RefSeq (protein)	NP_001886 NP_808227 NP_808228 NP_001349699 NP_001349700	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSNK2A1 yw CSNK2A1 a elwir hefyd yn CSNK2A1 protein , Casein kinase II subunit alpha a Casein kinase 2 alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSNK2A1.

• "Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. ". Int J Oncol. 2016. PMID 27098015.
• "De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features. ". Hum Genet. 2016. PMID 27048600.
• "Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers. ". J Leukoc Biol. 2017. PMID 27707883.
• "Genetic variants of the Wnt signaling pathway as predictors of aggressive disease and reclassification in men with early stage prostate cancer on active surveillance. ". Carcinogenesis. 2016. PMID 27515962.
• "Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia.". Leukemia. 2017. PMID 27479180.