CNTF

CNTF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CNT
Dynodwyr
Cyfenwau	CNTF, Hciliary neurotrophic factor
Dynodwyr allanol	OMIM: 118945 HomoloGene: 8288 GeneCards: CNTF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interleukin-6 receptor binding • GO:0001948, GO:0016582 protein binding • ciliary neurotrophic factor receptor binding • growth factor activity • cytokine activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • CRLF-CLCF1 complex • extracellular region • axon • extracellular space Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • cell differentiation • muscle organ morphogenesis • neuron development • regulation of retinal cell programmed cell death • nervous system development • ciliary neurotrophic factor-mediated signaling pathway • multicellular organism development • negative regulation of photoreceptor cell differentiation • GO:1901313 positive regulation of gene expression • GO:0072468 signal transduction • positive regulation of axon regeneration • positive regulation of cell population proliferation • astrocyte activation • positive regulation of tyrosine phosphorylation of STAT protein • growth • regulation of signaling receptor activity • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1270	n/a
Ensembl	ENSG00000242689	n/a
UniProt	P26441	n/a
RefSeq (mRNA)	NM_000614	n/a
RefSeq (protein)	NP_000605	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CNTF yw CNTF a elwir hefyd yn Ciliary neurotrophic factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q12.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CNTF.

• HCNTF

• "High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration. ". Protein Expr Purif. 2017. PMID 28323167.
• "Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. ". Cytokine Growth Factor Rev. 2015. PMID 26187860.
• "The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study. ". J Cereb Blood Flow Metab. 2015. PMID 25833344.
• "Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells. ". Folia Neuropathol. 2014. PMID 25118897.
• "Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.". J Alzheimers Dis. 2013. PMID 23948898.