CDKN2A

CDKN2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Dynodwyr
Cyfenwau	CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
Dynodwyr allanol	OMIM: 600160 HomoloGene: 55430 GeneCards: CDKN2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • NF-kappaB binding • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding • RNA binding • DNA binding • p53 binding • transcription factor binding • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity • disordered domain specific binding • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity Cydrannau o'r gell • cytoplasm • cytosol • senescence-associated heterochromatin focus • cnewyllyn cell • nuclear body • nucleoplasm • nucleolus • mitocondria • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1 phase • negative regulation of cell-matrix adhesion • cellular senescence • negative regulation of cell growth • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell population proliferation • G1/S transition of mitotic cell cycle • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • GO:0097285 apoptotic process • regulation of G2/M transition of mitotic cell cycle • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • protein stabilization • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • autophagy of mitochondrion • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • protein sumoylation • GO:1901313 positive regulation of gene expression • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity • amyloid fibril formation • negative regulation of protein neddylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1029	n/a
Ensembl	ENSG00000147889	n/a
UniProt	P42771 Q8N726	n/a
RefSeq (mRNA)	NM_000077 NM_001195132 NM_058195 NM_058196 NM_058197 NM_001363763	n/a
RefSeq (protein)	NP_000068 NP_001182061 NP_478102 NP_478104 NP_001350692 NP_478102.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN2A yw CDKN2A a elwir hefyd yn Tumor suppressor ARF (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN2A.

• "Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. ". Am J Surg Pathol. 2018. PMID 29112019.
• "Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families. ". J Invest Dermatol. 2017. PMID 28830827.
• "Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status. ". J Am Acad Dermatol. 2017. PMID 28818438.
• "Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome. ". Hum Pathol. 2017. PMID 28705710.
• "Obesity and Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.". Mol Cell Biol. 2017. PMID 28630279.