CD40LG

CD40LG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ALY, 1I9R, 3LKJ, 3QD6
Dynodwyr
Cyfenwau	CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
Dynodwyr allanol	OMIM: 300386 HomoloGene: 56 GeneCards: CD40LG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • CD40 receptor binding • tumor necrosis factor receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • bilen • cellbilen • integral component of plasma membrane • extracellular region • external side of plasma membrane • intracellular anatomical structure • cell surface • extracellular space Prosesau biolegol • leukocyte cell-cell adhesion • positive regulation of interleukin-12 production • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • platelet activation • positive regulation of endothelial cell apoptotic process • B cell proliferation • isotype switching • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of immune response • B cell differentiation • inflammatory response • T cell costimulation • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-4 production • positive regulation of interleukin-10 production • positive regulation of T cell proliferation • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	959	n/a
Ensembl	ENSG00000102245	n/a
UniProt	P29965	n/a
RefSeq (mRNA)	NM_000074	n/a
RefSeq (protein)	NP_000065	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD40LG yw CD40LG a elwir hefyd yn CD40 ligand (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq26.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD40LG.

• "CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression. ". J Immunol. 2017. PMID 28455435.
• "Elevated levels of soluble CD40 ligand are associated with antiphospholipid antibodies in patients with systemic lupus erythematosus. ". Clin Exp Rheumatol. 2017. PMID 28421990.
• "Association of CD40Lgene polymorphism with severe Plasmodium falciparummalaria in Indian population. ". J Vector Borne Dis. 2017. PMID 28352049.
• "CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas. ". Cancer Invest. 2017. PMID 28267402.
• "Serum concentration of CD40L is elevated in inflammatory demyelinating diseases.". J Neuroimmunol. 2016. PMID 27725124.