CCL17

CCL17
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NR2, 1NR4
Dynodwyr
Cyfenwau	CCL17, A-152E5.3, ABCD-2, SCYA17, TARC, C-C motif chemokine ligand 17
Dynodwyr allanol	OMIM: 601520 HomoloGene: 2246 GeneCards: CCL17
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • CCR chemokine receptor binding • signaling receptor binding • chemokine activity • CCR4 chemokine receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • G protein-coupled receptor signaling pathway • negative regulation of myoblast differentiation • monocyte chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • neutrophil chemotaxis • multicellular organism development • chemotaxis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6361	n/a
Ensembl	ENSG00000102970	n/a
UniProt	Q92583	n/a
RefSeq (mRNA)	NM_002987	n/a
RefSeq (protein)	NP_002978	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCL17 yw CCL17 a elwir hefyd yn C-C motif chemokine ligand 17 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCL17.

• "Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma. ". BMC Cancer. 2017. PMID 28178948.
• "Biomarkers for evaluation of treatment response in classical Hodgkin lymphoma: comparison of sGalectin-1, sCD163 and sCD30 with TARC. ". Br J Haematol. 2016. PMID 27610595.
• "Serum TARC levels are strongly correlated with blood eosinophil count in patients with drug eruptions. ". Allergol Int. 2017. PMID 27497618.
• "Targeting CD1c-expressing classical dendritic cells to prevent thymus and activation-regulated chemokine (TARC)-mediated T-cell chemotaxis in rheumatoid arthritis. ". Scand J Rheumatol. 2017. PMID 27250804.
• "Tumor-associated macrophage or chemokine ligand CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma.". Med Oncol. 2016. PMID 26781124.