CALCA

CALCA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JXZ,%%s1LS7
Dynodwyr
Cyfenwau	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Dynodwyr allanol	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • calcitonin receptor binding • GO:0001948, GO:0016582 protein binding • identical protein binding • signaling receptor binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • intracellular anatomical structure • extracellular region • axon • terminal bouton • soma • neuron projection • cnewyllyn cell • extracellular space Prosesau biolegol • cellular response to nerve growth factor stimulus • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • negative regulation of smooth muscle contraction • regulation of heart contraction • monocyte chemotaxis • negative regulation of blood pressure • positive regulation of cytosolic calcium ion concentration • cellular response to tumor necrosis factor • GO:0010260 heneiddio • vasodilation • cellular calcium ion homeostasis • response to heat • negative regulation of nervous system process • positive regulation of ossification • activation of adenylate cyclase activity • regulation of heart rate • detection of temperature stimulus involved in sensory perception of pain • negative regulation of ossification • response to pain • artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure • feeding behavior • inflammatory response • neuropeptide signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • activation of protein kinase activity • embryo implantation • negative regulation of bone resorption • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytosolic calcium ion concentration • leukocyte cell-cell adhesion • G protein-coupled receptor internalization • positive regulation of interleukin-1 alpha production • response to yeast • negative regulation of osteoclast differentiation • cell-cell signaling • antibacterial humoral response • positive regulation of macrophage differentiation • receptor internalization • regulation of blood pressure • protein phosphorylation • vasculature development • GO:0051636 defense response to Gram-negative bacterium • endothelial cell proliferation • positive regulation of interleukin-8 production • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of calcium ion transport into cytosol • innate immune response • endothelial cell migration • antifungal humoral response • GO:0051637 defense response to Gram-positive bacterium • antimicrobial humoral immune response mediated by antimicrobial peptide • amylin receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	796	n/a
Ensembl	ENSG00000110680	n/a
UniProt	P06881	n/a
RefSeq (mRNA)	NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950	n/a
RefSeq (protein)	NP_001029125.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALCA yw CALCA a elwir hefyd yn Calcitonin gene-related peptide 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALCA.

• "Calcitonin Gene-Related Peptide Induces HIV-1 Proteasomal Degradation in Mucosal Langerhans Cells. ". J Virol. 2017. PMID 28904199.
• "Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients. ". J Orthop Surg Res. 2017. PMID 28431586.
• "Procalcitonin Impairs Liver Cell Viability and Function In Vitro: A Potential New Mechanism of Liver Dysfunction and Failure during Sepsis?". Biomed Res Int. 2017. PMID 28255555.
• "The Diagnostic Value of Procalcitonin Versus Other Biomarkers in Prediction of Bloodstream Infection. ". Clin Lab. 2017. PMID 28182347.
• "Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia.". Horm Metab Res. 2017. PMID 28166595.