BUB1

BUB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2LAH, 4A1G, 4QPM, 4R8Q, 5DMZ
Dynodwyr
Cyfenwau	BUB1, BUB1A, BUB1L, hBUB1 mitotic checkpoint serine/threonine kinase
Dynodwyr allanol	OMIM: 602452 HomoloGene: 37910 GeneCards: BUB1
EC number	2.7.11.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding Cydrannau o'r gell • bilen • nucleoplasm • Cromosom • chromosome, centromeric region • cnewyllyn cell • kinetochore • cytosol Prosesau biolegol • phosphorylation • chromosome segregation • mitotic cell cycle checkpoint signaling • Cellraniad • regulation of chromosome segregation • protein phosphorylation • cell cycle • regulation of sister chromatid cohesion • cell population proliferation • GO:0022415 viral process • GO:0097285 apoptotic process • sister chromatid cohesion • meiotic sister chromatid cohesion, centromeric • mitotic spindle assembly checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	699	n/a
Ensembl	ENSG00000169679	n/a
UniProt	O43683	n/a
RefSeq (mRNA)	NM_001278616 NM_001278617 NM_004336	n/a
RefSeq (protein)	NP_001265545 NP_001265546 NP_004327	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BUB1 yw BUB1 a elwir hefyd yn Mitotic checkpoint serine/threonine-protein kinase BUB1 a BUB1 mitotic checkpoint serine/threonine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BUB1.

• BUB1A
• BUB1L
• hBUB1

• "Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes. ". Eur J Hum Genet. 2016. PMID 27552964.
• "Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. ". Elife. 2016. PMID 26885717.
• "Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1. ". PLoS One. 2015. PMID 26658523.
• "Bub1 is required for maintaining cancer stem cells in breast cancer cell lines. ". Sci Rep. 2015. PMID 26522589.
• "Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation.". Nat Commun. 2015. PMID 26399325.