BTG2

BTG2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DJU, 3E9V
Dynodwyr
Cyfenwau	BTG2, PC3, TIS21, BTG family member 2, BTG anti-proliferation factor 2, APRO1
Dynodwyr allanol	OMIM: 601597 HomoloGene: 31406 GeneCards: BTG2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular exosome • cytosol • cnewyllyn cell • cytoplasm Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • negative regulation of translation • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • associative learning • GO:0009373 regulation of transcription, DNA-templated • GO:1904578 response to organic cyclic compound • dentate gyrus development • negative regulation of neural precursor cell proliferation • response to mechanical stimulus • response to peptide hormone • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • response to electrical stimulus • response to organic substance • transcription, DNA-templated • cellular response to DNA damage stimulus • central nervous system neuron development • response to organonitrogen compound • neuron differentiation • skeletal muscle cell differentiation • neuron projection development • GO:0100026 DNA repair • anterior/posterior pattern specification • protein methylation • negative regulation of cell population proliferation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7832	n/a
Ensembl	ENSG00000159388	n/a
UniProt	P78543	n/a
RefSeq (mRNA)	NM_006763	n/a
RefSeq (protein)	NP_006754	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BTG2 yw BTG2 a elwir hefyd yn BTG anti-proliferation factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BTG2.

• PC3
• APRO1
• TIS21

• "BTG2: a rising star of tumor suppressors (review). ". Int J Oncol. 2015. PMID 25405282.
• "Loss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance. ". Cancer Sci. 2014. PMID 24698107.
• "BTG2 Is Down-Regulated and Inhibits Cancer Stem Cell-Like Features of Side Population Cells in Hepatocellular Carcinoma. ". Dig Dis Sci. 2017. PMID 29098552.
• "Inhibitory effects of B‑cell translocation gene 2 on skin cancer cells via the Wnt/β‑catenin signaling pathway. ". Mol Med Rep. 2016. PMID 27510158.
• "BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.". Int J Clin Exp Pathol. 2015. PMID 26722427.